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Clinical Trials in Egypt / NCT06717997
Starting soon Not applicable

The Placental Thickness and Pregnancy Outcomes in Placenta Previa Women

NCT06717997 · tracked via the Priya Life Science Egypt tracker
Sponsor
Assiut University
Phase
Not applicable
Started
2025-01
Last updated
2024-12-05

Condition(s) studied

Placenta Accreta

Investigational drug(s) / intervention(s)

ultrasound

ultrasound: The placenta thickness will be performed on transabdominal images obtained in a longitudinal plane. Three measurements will be performed at the thickest portion of the placenta. The average of these three measurements was used for statistical analysis. The cohorts will be classified into 1) thick placenta (\>4 cm) and average placenta (2-4 cm).

Study summary

Placenta previa is the placenta overlying the cervical os. Placenta previa is about 1 in 200 pregnancies. The risk factors are the increasing rate of cesarean section and previous uterine surgery. Placenta previa is associated with many adverse complications; the most serious one is related to maternal hemorrhage. The diagnosis of placenta previa is done by trans-abdominal and trans-vaginal ultrasonography, which can document the placental edge's relationship to the internal os. Placenta accreta spectrum disorder is defined when trophoblastic invades the myometrium. The Placenta accreta spectrum can be categorized as: placenta accreta, placenta increta, and placenta percreta.

The clinical utility of placental thickness is an area of ongoing research in placenta previa. Prior studies have demonstrated an association between mid-trimester placental thickness and placenta accreta spectrum. Despite the presence of many studies in characterizing placental thickness, most studies have focused primarily on the placental accreta spectrum lacking information about other fetal and maternal complications. Symptomatic (bleeding) placenta previa is associated with increased maternal and neonatal morbidity and mortality. In addition; the mechanism that involves bleeding is unclear. It is usually related to uterine contractions, cervical effacement, and dilation leading to separation of the placenta from the underlying decidua.

Eligibility

Sex
FEMALE
Min age
20 Years
Max age
35 Years
Healthy volunteers
No
Inclusion Criteria: 1. Pregnant women from 32-34 weeks. 2. Pregnant women with singleton pregnancy. 3. Women with placenta previa. 4. Placenta previa with minimal vaginal bleeding or haven't any vaginal bleeding. 5. Women without any medical disorders. 6. Women should be living in a nearby area to make follow-up and early transportation is reasonably possible. Exclusion Criteria: 1. Women with severe bleeding necessitate immediate delivery. 2. Women with confirmed fetal malformation. 3. If associated with abruptio placentae. 4. Women who will refuse to participate.

Primary outcome measure(s)

  • number of women with placenta accreta — 3 weeks

Trial sites (1)

FacilityCityRegionStatus
Women Health Hospital - Assiut university Asyut Egypt

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06717997 on ClinicalTrials.gov ↗ ← All trials in Egypt