Regenerative Ability of Immature Necrotic Permanent Teeth Using Different Scaffolds

Condition(s) studied

Investigational drug(s) / intervention(s)

Platelet rich fibrin: PRF membrane is placed as a scaffold inside the canal with no hyaluronic acid

hyaluronic acid: hyaluronic acid gel is placed as a scaffold inside the canal with no PRF

no scaffold: initiate bleeding using hand files size beyond apex with sharp strokes with no PRF or hyaluronic acid placed

Study summary

The goal of this clinical trial is to compare effect of different scaffolds on the regenerative potential of young permanent immature teeth with necrotic pulp. The main question it aims to answer is:

is there difference in regenerative potential using Hyaluronic acid and platelets rich fibrin as scaffolds in permanent immature teeth with necrotic pulp? participants will undergo regeneration protocol including hyaluronic acid and platelets rich fibrin as scaffolds Researchers will compare \[hyaluronic acid , platelets rich fibrin , and no scaffold \] to see the regenerative potential

Eligibility

Primary outcome measure(s)

• Clinically by absence of pain and/or swelling — 1 year
  absence of pain is measured clinically by absence of pain in response to percussion and palation in relation to the related tooth
• absence or change of periapical radiolucency. — 1 year
  absence or change of periapical radiolucency is measured by standardized radiographs (paralleling technique every 3 months and cbct after 1 year)

Trial sites (1)

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