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Clinical Trials in Egypt / NCT06674564
Active, not recruiting Not applicable

Effect of Zinc and Probiotics Supplementation on Laryngeal Cancer Patients Undergoing Laryngectomy Surgery to Improve Prognosis and Better Wound Healing

NCT06674564 · tracked via the Priya Life Science Egypt tracker
Sponsor
Ain Shams University
Phase
Not applicable
Started
2024-09-09
Last updated
2024-11-05

Condition(s) studied

Laryngectomy

Investigational drug(s) / intervention(s)

Zinc Acetate 50 Mg Oral CapsuleProbiotic

Zinc Acetate 50 Mg Oral Capsule: zinc suppose to improve immunity and wound healing after laryngectomy

Probiotic: probiotics lowering infections rates and improving outcomes after surgery

Study summary

using zinc and probiotics supplementation for providing better prognosis for laryngeal cancer patients under going total or partial laryngectomy.

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: * All patients presenting to ENT department will be subjected eligible Adults patients newly diagnosed at outpatient clinic with laryngeal cancer at any stage and will undergo total/partial laryngectomy surgery. Patients with Level of hemoglobin \>9 mg/dl and serum albumin 3g/dl According to (Crosetti et al. 2021). Staging of laryngeal cancer according to the American Joint Committee on Cancer (AJCC) 8th edition by TNM system. Exclusion Criteria: \- 1. Impaired renal function sr.cr≤2.5 (zinc clearance). 2.Previous history of cancer diseases in other sites( previous chemotherapy or radiation). 3.Hypersensitivity to probiotics and zinc.

Primary outcome measure(s)

  • wound healing — 21 days after surgery, a month total
    The role of zinc and probiotics supplementations on the rate of wound healing (pharyngeal reconstruction.
  • occurrence of percutaneous fistula — 21 days after surgery - total a month
    according to john et al grading 3- 4 grade
  • rate of infections — 21 days after surgery - a month total
    rate of infection of wound after total /partial laryngectomy
  • starting of oral feeding — 21 days after surgery-30 days total
    reconstruction of pharynx post operative and start oral feeding

Trial sites (1)

FacilityCityRegionStatus
Ain shams university hospital Cairo Al Abbasya

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06674564 on ClinicalTrials.gov ↗ ← All trials in Egypt