Effects of Petroleum Compounds on Psychological Health and Cognitive Functions

Condition(s) studied

Investigational drug(s) / intervention(s)

whey protien: Whey, the supernatant of yogurt and a byproduct of cheese, is rich in protein and consists of β-lactalbumin, α-lactoglobulin, immunogloblin, bovine serum albumin, and other minor proteins. Whey protein is a globally consumed food material and is well known for its health benefits

Study summary

Over the last decade, awareness of the effects of hydrocarbon fuels on neurodegenerative disorders has increased significantly, as they are ubiquitous environmentally toxic chemicals that affect the central nervous system and result in irreversible neuronal damage, as many hydrocarbons can cross the blood-brain barrier through multiple pathways and cause direct toxicity.

Eligibility

Primary outcome measure(s)

• Effects of petroleum compounds on psychological health and cognitive functions of petrol station workers in Assiut — 1 year
  for psychological assessment through symptom check list 90 (revised) and cognitive function through the Mini Mental State Examination (30 points: 25-30: normal; 21-24: mild cognitive impairment; 10-20: moderate; and 0-9: severe) and Wecksler memory scale (higher score indicates better performance, while lower score indicates memory impairment)
• To explore the relation between the level of petroleum hydrocarbon metabolites and the severity of psychological heath and cognitive functions disturbance of petrol station workers — 1 year
  urinary metabolites for BTEX through GS-MS
• To explore the role of supplements with whey protein in ameliorating these effects — 1 year
  20 g of whey protein 3 times per week for 8 weeks will be given to workers with cognitive difficulties

Trial sites (1)

More Assiut University trials in Egypt