Bronchoscopic Levofloxacin, Gentamicin, or Sham for Acute Exacerbation of Bronchiectasis

Condition(s) studied

Investigational drug(s) / intervention(s)

Local instillation of gentamicin and Budesonide: Bronchoscopic local instillation of gentamicin and Budesonide

Local instillation of Levofloxacin and Budesonide: Bronchoscopic local instillation of Levofloxacin and Budesonide

Bronchoscopic mechanical secretion suction and lavage: Bronchoscopic mechanical secretion suction and lavage

Sham Bronchoscopy: Bronchoscopy for airway visualization only, no lavage or drug instillation (sham procedure).

Study summary

Randomized single-center trial evaluating whether bronchoscopic instillation of levofloxacin or gentamicin improves outcomes compared to a sham bronchoscopic procedure in adult ICU patients with non-cystic fibrosis bronchiectasis requiring invasive mechanical ventilation. The primary outcome is a ranked composite of in-hospital mortality and time to ventilator liberation. Safety and procedural adverse events are closely monitored.

Eligibility

Primary outcome measure(s)

• Days for weaning from mechanical ventilation — one month
  days of mechanical ventilation will be measured and compared between drug and conventional groups

Trial sites (1)

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