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Clinical Trials in Egypt / NCT04217733
Recruiting Phase 3

Ethosuximide and Pentoxifylline in the Treatment of Abdominal Pain Related to Irritable Bowel Syndrome

NCT04217733 · tracked via the Priya Life Science Egypt tracker
Sponsor
Tanta University
Phase
Phase 3
Started
2019-11-01
Last updated
2020-01-03

Condition(s) studied

IBS - Irritable Bowel Syndrome

Investigational drug(s) / intervention(s)

pentoxyifyllineMebeverineethosuximide

pentoxyifylline: Pentoxyifylline two times daily for 3 months

Mebeverine: Mebeverine 3 times for 3 months

ethosuximide: ethosuximide 3 times for 3 months

Study summary

Ethosuximide and pentoxifylline in the treatment of abdominal pain related to irritable bowel syndrome

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * • Age ≥ 18 years, * Man and Women, Negative pregnancy test and effective contraception, * IBS defined by the Rome criteria IV * During the previous seven days the inclusion visit, average numeric rating scale (NRS) pain ≥ 4. * IBS Treatment stable for 1 month Exclusion Criteria: * • Breastfeeding * Diabetic patients * Significant liver function abnormalities (transaminases\> 3N, cholestasis) and moderate renal disease (MDRD \<60 ml / min) * Addiction to alcohol and / or drugs, * Antiepileptic drugs taken (epilepsy or chronic pain) * Chronic pain of greater intensity than that related to IBS, * Known Allergyto succinimides (ethosuximide, methsuximide, phensuximide) and pentoxifylline. * History or current severe depression (hospitalization, long-term antidepressant treatment) * Psychotic disorders,

Primary outcome measure(s)

  • Number of patients with improved Visual analog scales (VAS) for assessment of pain in IBS — 6 months
    the number of patients with improved Visual analog scales (VAS) for assessment of pain in IBS

Trial sites (1)

FacilityCityRegionStatus
Sherief Abd-Elsalam Tanta Egypt Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04217733 on ClinicalTrials.gov ↗ ← All trials in Egypt