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Clinical Trials in Denmark / NCT07690358
Recruiting Not applicable

Concentrations of Nitrous Oxide in Blood, Exhaled Air and Urine After Various Types of Exposure.

NCT07690358 · tracked via the Priya Life Science Denmark tracker
Sponsor
University of Aarhus
Phase
Not applicable
Started
2026-06-01
Last updated
2026-07-08

Condition(s) studied

Intoxication by Drug

Investigational drug(s) / intervention(s)

Nitrous Oxide 99 %Nitrous Oxide + Oxygen Gas

Nitrous Oxide 99 %: Passive exposure to Nitrous Oxide

Nitrous Oxide + Oxygen Gas: Midwifes are exposed through work in a delivery room

Study summary

The study examines the concentrations of nitrous oxide that are achieved in blood, exhaled air, and urine after three different exposures to nitrous oxide:

inhalation of three or four cartridges of nitrous oxide released in a car cabin in a switched-off car, consumption of 100 g of whipped cream in which nitrous oxide is used as a propellant, and exposure through work as a midwife in a delivery room.

The concentrations in blood and exhaled air are measured for up to 1 hour after exposure, and in urine for up to 2 hours after exposure. The concentrations in blood and urine are measued with gas chromatography and mass spectrometry, while the concentration in exhaled air is measured by a sensor using an NDIR sensor (Olythe, France).

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
For arm 1, 2, and 3: Inclusion Criteria: * Age 18-65 years * Able to understand Danish * Willing to use effective contraception for 24 hours after the end of exposure (oral contraceptives, contraceptive implant, transdermal patch, vaginal ring, or injectable contraceptives) * Written informed consent Exclusion Criteria: * Current or past abuse of drugs, nitrous oxide (N₂O), or alcohol * A psychiatric disorder requiring medical treatment, including severe depression * A diagnosis of epilepsy * Symptoms of peripheral neuropathy * Significant cardiac or pulmonary disease * Previous allergic or adverse reaction to N₂O * Diving within the past 2 days * Inability to refrain from diving for 2 days after the study * Occupational exposure to N₂O * Use of N₂O within the past 3 months * Treatment with methotrexate, benzodiazepines, opioids, or other centrally depressant drugs * Recent intraocular gas injection * Known impaired liver or kidney function * Pregnant or breastfeeding women (fertile women, defined as amenorrhea for less than 12 months, must have a negative hCG pregnancy test prior to receiving the study intervention)

Primary outcome measure(s)

  • Detection time of Nitrous Oxide in blood — From end of exposure to 1 hour after end of exposure
    The time after exposure in which Nitrous Oxide can be detected in blood

Trial sites (1)

FacilityCityRegionStatus
Department of Forensic Medicine Aarhus Denmark Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07690358 on ClinicalTrials.gov ↗ ← All trials in Denmark