The Role of Janus Kinase (JAK) and Voltage-gated Sodium Channels (Nav) on Pain and Itch

NCT07203274 · tracked via the Priya Life Science Denmark tracker

Sponsor

Aalborg University

Phase

Not applicable

Started

2026-05-01

Last updated

2026-04-23

Condition(s) studied

Itchiness

Investigational drug(s) / intervention(s)

Delgocitinib cream →lidocaine cream →Lidocaine+DelgocitinibVehicle (placebo)Histamine Dihydrochloride (HDC)Cowhage (Mucuna Pruriens)

Delgocitinib cream: Delgocitinib cream

lidocaine cream: Lidocaine cream

Lidocaine+Delgocitinib: The two cream will me mixed togheter

Vehicle (placebo): Vehicle Cream

Histamine Dihydrochloride (HDC): One drop of histamine will be applied on the selected areas and pierced with a lancet

Cowhage (Mucuna Pruriens): About 30 spicules will be applied on the selected areas and inserted manually

Study summary

It is well known that itch and pain have many communalities in terms of pathways and molecules involved. Therefore, it is very important to investi-gate different substances that work against both pain and itching. The substances delgocitinib and lidocaine have both been shown to relieve various types of pain. We therefore assume that these creams will be also able to relieve itching. The purpose of this trial experiment is therefore to investigate the effect of delgocitinib, lidocaine and their combination on experimentally induced itching.

Eligibility

Sex

ALL

Min age

18 Years

Max age

60 Years

Healthy volunteers

Accepted

Inclusion Criteria: * Healthy men and women * 18-60 years * Speak and understand English Exclusion Criteria: * Pregnancy or lactation * Drug addiction defined as any use of cannabis, opioids, or other drugs that may cause addiction. * Previous or current history of neurological, dermatological (e.g., AD, psoriasis, etc.), immunological, musculoskeletal, cardiac disorder or psychiatric diagnoses that may affect the results (e.g., neuropathy, muscular pain in the upper extremities, anxiety, depression, schizophrenia, etc.) * Moles, wounds, scars, or tattoos in the area to be treated or tested * Current use of medications that may affect the trial such as antihistamines and painkillers * use of antihistamines should be discontinued 72 hours before the experiment and all topical agents and emollients should be discontinued 24 hours before the experiment). * Use of systemic and topical corticosteroids * Previous traumatic experience of an electrical accident * Application of moisturizing lotion of the volar site of the forearms (24 hours before study start) * Skin diseases * Consumption of alcohol or painkillers 24 hours before the study days and between these * Acute or chronic pain and itch * Known allergy/intolerance to lidocaine/phenytoin/mepyramine * Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical studies) * Lack of ability to cooperate

Primary outcome measure(s)

Measuring itch by computerized Visual Analog Scale Scoring — Day 1
We will ask the subjects to rate the sensation of itch on a 100 mm VAS scale ranging from 0 to 100 where 0 indicates "no itch" and 100 indicates "worst itch imaginable".
Measuring itch by computerized Visual Analog Scale Scoring — Day 2
We will ask the subjects to rate the sensation of itch on a 100 mm VAS scale ranging from 0 to 100 where 0 indicates "no itch" and 100 indicates "worst itch imaginable".
Superficial blood perfusion — Day 1
Superficial blood perfusion — Day 2

Trial sites (1)

Facility	City	Region	Status
Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University Selma Lagerløfs Vej 249 9260 Gistrup, Denmark	Gistrup	Denmark

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07203274 on ClinicalTrials.gov ↗ ← All trials in Denmark