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Clinical Trials in Denmark / NCT06888908
Recruiting Observational

Changes in Perioperative Blood Volume and Fluid Distribution in Patients Undergoing Primary Total Hip Replacement.

NCT06888908 · tracked via the Priya Life Science Denmark tracker
Sponsor
Copenhagen University Hospital, Hvidovre
Phase
Observational
Started
2025-03
Last updated
2025-03-21

Condition(s) studied

Hip Arthroplasty Replacement

Study summary

Clinical assessment of bleeding and calculation of perioperative blood loss do not provide an accurate estimate of blood volume. This makes rational fluid management difficult, which is of high importance for patient-related outcomes. The availability of carbon monoxide(CO)-rebreathing allows for simple, non-invasive and precise measurement of changes in blood volume.

The purpose of the study is to investigate and describe changes in blood volume and fluid distribution perioperative in patients undergoing total hip arthroplasty. Furthermore, to investigate the association between changes in blood volume and incidence of orthostatic insufficiency.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Patients scheduled for an elective total hip arthoplasty (THA) in a standardized fast track setting. * Capable of participating in CO-rebreathing measurement * Age ≥ 18 years * Able to speak and understand Danish * Has provided written informed consent. Exclusion Criteria: * Intraoperative blood loss exceeding 750 mL. * Perioperative need for a blood transfusion. * Confirmed or suspected coagulopathies. * Factors that make CO-rebreathing measurement impossible. * Known orthostatic intolerance. * American Society of Anesthesiologists physical status (ASA) classification ≥ 4.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Hvidovre University Hospital Copenhagen Denmark Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06888908 on ClinicalTrials.gov ↗ ← All trials in Denmark