A Study to Evaluate the Efficacy and Safety of JNJ-77242113 (Icotrokinra) in Biologic-naïve Participants With Active Psoriatic Arthritis
Condition(s) studied
Investigational drug(s) / intervention(s)
Icotrokinra: Icotrokinra will be administered.
Placebo: Placebo will be administered.
Active reference comparator: Active reference drug will be administered.
Study summary
The purpose of this study is to evaluate the efficacy of icotrokinra compared to placebo in participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.
Eligibility
Primary outcome measure(s)
- Proportion of Participants who Achieve an American College of Rheumatology (ACR) ACR 20 Response at Week 16 — Week 16
The ACR 20 responders are participants with an improvement of greater than or equal to (\>=) 20 percent (%) from baseline in both the tender and swollen joint count and in at least 3 of the 5 assessments (patient's assessment of pain visual analog scale (VAS), patient's global assessment of disease activity VAS scale, physician's global assessment of disease activity VAS scale, health assessment questionnaire and C-reactive protein).
Trial sites (155)
| Facility | City | Region | Status |
|---|---|---|---|
| Arthritis and Rheumatism Associates ARA Jonesboro | Jonesboro | Arkansas | |
| Omega Research Consultants | DeBary | Florida | |
| Integral Rheumatology And Immunology Specialists | Plantation | Florida | |
| Clinical Research of West Florida | Tampa | Florida | |
| Willow Rheumatology and Wellness PLLC | Willowbrook | Illinois | |
| Joint and Muscle Research Institute | Charlotte | North Carolina | |
| Altoona Center For Clinical Research | Duncansville | Pennsylvania | |
| Arthritis and Rheumatology Research Institute | Allen | Texas | |
| Naiara Alvarez MD Integrative Rheumatology of South TX | Harlingen | Texas | |
| Cosultorios Reumatologógicos Pampa | Buenos Aires | Argentina | |
| Mindout Research | Buenos Aires | Argentina | |
| Hospital Central Militar Cirujano Mayor Dr Cosme Argerich | Buenos Aires | Argentina | |
| Arsema | Ciudad de Buenos Aires | Argentina | |
| Centro Medico Privado de Reumatologia Tucuman | Ciudad de San Miguel de Tucuman | Argentina | |
| Consultora Integral de Salud SRL | Córdoba | Argentina | |
| MR Medicina Reumatologica | San Fernando | Argentina | |
| Instituto Medico De Alta Complejidad (IMAC) | San Isidro | Argentina | |
| Ipswich Hospital | Ipswich | Australia | |
| Rheumatology Research Unit | Maroochydore | Australia | |
| BJC Health | Parramatta | Australia | |
| Queen Elizabeth Hospital | South Woodville | Australia | |
| Royal Darwin Hospital | Tiwi | Australia | |
| MC Medtech Services Ltd | Haskovo | Bulgaria | |
| Exacta Medica | Pleven | Bulgaria | |
| Medical Center Artmed | Plovdiv | Bulgaria | |
| Medical Center Teodora | Rousse | Bulgaria | |
| Peking University Third Hospital | Beijing | China | |
| Beijing Tong Ren Hospital Capital Medical University | Beijing | China | |
| The First Bethune Hospital of Jilin University | Changchun | China | |
| Xiangya Hospital Central South University | Changsha | China | |
| West China Hospital Sichuan University | Chengdu | China | |
| Sichuan Provincial Peoples Hospital | Chengdu | China | |
| The First Affiliated Hospital of Chongqing Medical University | Chongqing | China | |
| Nanfang Hospital of Southern Medical Hospital | Guangzhou | China | |
| The Affiliated Hospital of Guizhou Medical University | Guiyang | China | |
| Linyi City People Hospital | Linyi | China | |
| Jiangxi Provincial Peoples Hospital | Nanchang | China | |
| The Second Affiliated Hospital of Nanchang University | Nanchang | China | |
| Affiliated Hospital of Nantong University | Nantong | China | |
| Pingxiang People's Hospital | Pingxiang | China |
+ 115 more sites — see the full list on the official registry below.
More Janssen Research & Development, LLC trials in Denmark
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06878404 on ClinicalTrials.gov ↗ ← All trials in Denmark