Recompensation in Alcohol Related Hepatitis

Condition(s) studied

Investigational drug(s) / intervention(s)

Motivational enhancement therapy: The intervention consists of three motivational interviews with the focus to enhance the participants motivation to enter treatment of alcohol use disorder. the interviews are structured and based on the model Motivational enhancement therapy.

Study summary

Genetic activity and metabolic changes may be part of the pathogenesis in alcohol related hepatitis. We do not know exactly how alcohol cessation affects liver functions and metabolism.

The aim of this study is to assess the impact of alcohol cessation in patients with alcohol related hepatitis and gain knowledge of the metabolic and genetic functions of the liver during remission and recompensation from alcohol related hepatitis.

The study will assess

1. The effect of alcohol cessation on the liver.
2. The biological mechanisms involved in healing after alvohol-cessation
3. The effect of motivational enhcament therapy in alcohol cessation after alcohol related hepatitis.
4. The metabolic changes of lipids and proteins in the liver Participants are offered motivational enhancement therapy and standard of care.

Eligibility

Primary outcome measure(s)

• Change from baseline in the proteomic profile — 12 months
  Change from baseline to 12 months in the proteomic profile in the liver tissue
• Change from baseline in the lipidomic profile — 12 months
  Changes from basline to 12 months in the lipidomic profile in the liver tissue
• Number of participants in recompensation — 12 months
  Number of patients who achieve recompensation/remission from AH after 12 months

Trial sites (1)