Conservative Management vs. Arthroplasty in Knee Osteoarthritis

Condition(s) studied

Investigational drug(s) / intervention(s)

Non-Surgical Intervention: After referral from the general practitioner to the orthopedic department, the patient is offered a 3-month non-operative treatment program. The conservative program consists of several elements that are offered on an individual basis. The program consists of 3 main elements: * Patient education/information * Specialized exercise supervised by a physiotherapist * Weight loss counseling with a dietician

Current practice: After referral from the general practitioner to the orthopedic department, the patient is assessed by an orthopedic surgeon in the out-patient clinic according to standard practice with a focus on symptoms, history, physical examination, radiography, and an appraisal of the patient's expectations. If an indication for knee arthroplasty is found, the patient is offered knee arthroplasty, and if the patient accepts the offer, he/she is scheduled according to usual practice. If a patient declines the offer, the patient is informed that the hospital cannot offer any additional service, and the patient is referred back to primary care.

Study summary

The goal of this observational study is to learn about the long-term effects of a non-surgical management programme in people with osteoarthritis that are eligible for a knee joint replacement surgery to treat their knee osteoarthritis (KOA). The main question it aims to answer is:

\- Does the non-surgical management programme reduce the proportion of referred patients who are treated with a knee arthroplasty without reducing the health-related quality of life over a two-year perspective?

Eligibility

Primary outcome measure(s)

• Proportion of patients undergoing knee arthroplasty surgery — 2 years
  Percentage of patients who undergo knee replacement surgery in the target joint during the 2-year observation period.
• Euroqol 5 dimensions questionnaire (EQ5D) — Average over 2 years (collected at month 0 (enrollment), 3, 6, 9, 12, 18 and 24)
  EQ5D is a standardized patient-reported instrument for use as a measure of health outcome and quality of life. EQ5D is designed for self-completion by respondents and is ideally suited for use in surveys. We will use standard Danish value set to convert the five EQ-5D-5L answers to a single index utility score, and ulti-mately to calculate the QALYs gained by the treatment.

Trial sites (6)

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