Resistance Training and Corticospinal Excitability in Multiple Sclerosis

NCT06374108 · tracked via the Priya Life Science Denmark tracker

Sponsor

University of Aarhus

Phase

Not applicable

Started

2024-05-01

Last updated

2024-12-11

Condition(s) studied

Multiple Sclerosis

Investigational drug(s) / intervention(s)

Progressive resistance training

Progressive resistance training: The RT exercise regime will focus on lower extremity exercises (60-90% of 1 repetition maximum) as well as incorporating functional exercises.

Study summary

The goal of the present study is to investigate effects of progressive resistance training on central nervous system functioning (corticospinal excitability (CSE)) and walking capacity in persons with multiple sclerosis (pwMS). A total of 54 pwMS will be enrolled and randomized into 1 of 3 groups: high dose resistant training (RT), low dose RT, and waitlist control.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age ≥ 18 years * MS diagnosis according to the McDonald diagnostic criteria * Shows impairments in walking capacity * Ability to self transport to test and exercise Exclusion Criteria: * Pregnancy * Neurological or other comorbidities that affects the nervous system * Relapse within the past 2 months * Pacemaker or metallic implants * Hypertension (medically unregulated) * Participation in structured RT over the past 3 months (≥ 2 sessions/week).

Primary outcome measure(s)

MEP/Mmax ratio — Change from Baseline to 10 weeks
Cortical excitability measured as amplitude percentage ratio between MEP (resting) and Mmax (Cmap of TA). Unit (intended): %

Trial sites (2)

Facility	City	Region	Status
Department of Public Health	Aarhus	Central Jutland	Recruiting
Department of Nutrition, Exercise and Sports, University of Copenhagen	Copenhagen	Copenhagen N	Recruiting

More University of Aarhus trials in Denmark

Probiotic Treatment of Orthodontic Patients Recruiting

BPA vs. PEA in CTEPH Recruiting

Precision Treatment of Lumbar Spine Surgery Through Advanced Nerve Root Blockade Recruiting

IMPROVE: Circulating Tumor DNA Analysis to Optimize Treatment for Patients With Colorectal Cancer Active, not recruiting

Danish Access to Support and Help (DASH): Increasing Access to an Evidence-based Intervention for Children With ADHD and Their Parents Enrolling by invitation

Other trials for the same condition

Sacral Neuromodulation for Neurogenic Lower Urinary Tract, Bowel and Sexual Dysfunction Recruiting

MS-DETECT: Early Detection of Multiple Sclerosis Progression With MSCopilot® Detect Active, not recruiting

Implementation of an Advanced Telerehabilitation Solution for People With Multiple Sclerosis Starting soon

Illuminating New Paths in the Treatment of Multiple Sclerosis Relapses - Early and Specialized Rehabilitation Recruiting

At Home Use of Stimulation Suits for Managing MS Symptoms Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06374108 on ClinicalTrials.gov ↗ ← All trials in Denmark