The Oxford Risk Factors And Non-Invasive Imaging Study

Condition(s) studied

Study summary

ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.

Eligibility

Primary outcome measure(s)

• Cardiac and all cause mortality — 15 years
  Using novel image analysis methods, clinical risk factors, and blood biomarkers to predict future cardiac and all-cause mortality over a period of 15 years post CT scan.
• Non-fatal vascular events — 15 years
  Using novel image analysis methods, clinical risk factors, and blood biomarkers to predict future non-fatal vascular events over a period of 15 years post CT scan.
• Cardiac and non-cardiac findings by Computed Tomography — 15 years
  Using novel image analysis methods, clinical risk factors, and blood biomarkers to detect pathology from Computed Tomography images.
• Progression of disease — 15 years
  Using novel image analysis methods, clinical risk factors, and blood biomarkers to predict progression of cardiometabolic diseases over a period of 15 years post index CT scan.

Trial sites (45)

+ 5 more sites — see the full list on the official registry below.

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