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Clinical Trials in Denmark / NCT05063955
Recruiting Observational

Mechanism of Sarcopenia in Heart Failure

NCT05063955 · tracked via the Priya Life Science Denmark tracker
Sponsor
Aarhus University Hospital
Phase
Observational
Started
2020-12-02
Last updated
2023-12-26

Condition(s) studied

Heart FailureSarcopeniaCachexia

Study summary

The aim of the study is to provide information on the interaction between socioeconomic factors, daily physical activity, nutrition and lifestyle on loss of muscle mass and muscle function in patients with heart failure.

Eligibility

Sex
ALL
Min age
18 Years
Max age
90 Years
Healthy volunteers
Accepted
Inclusion Criteria: 1. Ability to provide valid informed consent. 2. Heart failure with preserved, mid-range or reduced ejection fraction (NYHA I-IV) according to European Society of Cardiology guidelines. Exclusion Criteria: 1. Cancer requiring treatment (e.g. prostate cancer on watchful waiting does not exclude patients). 2. Severe musculoskeletal or neurological disability. 3. Severe lung disease with a forced expiratory volume 1 \< 40% of predicted. Treatment with anticoagulants (warfarin, apixaban, edoxaban, dabigatran and rivaroxaban) is an exclusion criterion for muscle biopsy. Patients with anticoagulant treatment will be invited to participate in the study without muscle biopsy. 4. Other comorbidities that prevent the patient from participating in the study examinations as judged by the investigator.

Primary outcome measure(s)

  • Physical performance, peak VO2 — From baseline to 12 and 36 months
    Change in peak oxygen uptake (peak VO2), measured in ml O2/kg/min
  • Physical performance, walking distance — From baseline to 12 and 36 months
    Change in walking distance (6MWT) in meters
  • Physical performance, muscle strength — From baseline to 12 and 36 months
    Change in knee extension/flexion isokinetic strength (assessed by peak torque, Nm) and isometric strength (assessed by peak torque, Nm)

Trial sites (1)

FacilityCityRegionStatus
Aarhus University Hospital Aarhus N Denmark Recruiting

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Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure Recruiting
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity Recruiting
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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05063955 on ClinicalTrials.gov ↗ ← All trials in Denmark