Prevalence and Clinical Impact of Airway Opening Pressure in Post-Cardiac Surgery Patients

Condition(s) studied

Investigational drug(s) / intervention(s)

Airway opening pressure: Airway opening pressure will be measured within one hour of intensive care unit admission (using a standardized low-flow insufflation maneuver flow 5-6 LPM). The inflection point on the pressure-time or pressure-volume waveform- depending on ventilator model-will define the airway opening pressure.

Study summary

Airway opening pressure is a key parameter in assessing respiratory mechanics. Current practice primarily relies on indirect assessments of lung mechanics, but growing evidence suggests that direct airway opening pressure measurement could enhance individualized ventilatory strategies. Significant airway opening pressure suggests incomplete alveolar recruitment at end-expiration, which may contribute to ventilation-perfusion mismatch, increased respiratory effort, and postoperative pulmonary complications such as atelectasis and impaired gas exchange. Determining the prevalence and clinical relevance of significant airway opening pressure in post-cardiac surgery patients could contribute to more personalized respiratory strategies and improve postoperative care.

Eligibility

Primary outcome measure(s)

• Prevalence of significant airway opening pressure — up to 1 hour after intensive care admission
  airway opening pressure ≥ 5 cmH₂O

Trial sites (1)

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