Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity

NCT07027566 · tracked via the Priya Life Science Brazil tracker

Sponsor

Universidade Federal do Para

Phase

Phase 1

Started

2025-07-25

Last updated

2025-06-18

Condition(s) studied

Dentin Sensitivity

Investigational drug(s) / intervention(s)

Potassium nitrate and sodium fluorideCannabidiol (CBD) Gel →Natrosol 4% Gel

Potassium nitrate and sodium fluoride: Gel with 5% potassium nitrate and 2% sodium fluoride gel of 5% potassium nitrate and 2% sodium fluoride for topical application to teeth before bleaching with hydrogen peroxide

Cannabidiol (CBD) Gel: Cannabidiol gel for teeth ( 2% cannabidiol oil) before bleaching with hydrogen peroxide

Natrosol 4% Gel: placebo gel (natrosol-based gel 4%) for topical application to teeth before bleaching with hydrogen peroxide.

Study summary

The goal of this clinical trial will be to evaluate the effect applying an experimental gel based on cannabidiol oil (CBD) on tooth sensitivity induced by tooth bleaching with 35% hydrogen peroxide (HP). Volunteers will be selected and allocated to the following groups: GP - placebo gel, GCBD - experimental cannabidiol gel and GKF - Potassium Nitrate and Sodium Fluoride Gel. In each group, the corresponding desensitizing gel will be applied to on the teeth for 10 minutes. All groups will then undergo in-office whitening treatment with 35% hydrogen peroxide. Patients will be instructed to record tooth sensitivity on a daily basis during the 21 days of follow-up. Pain intensity will be measured using a visual analog scale (VAS), while the risk of developing sensitivity will be recorded after each session of the whitening procedure, with two response option.

Eligibility

Sex

ALL

Min age

18 Years

Max age

40 Years

Healthy volunteers

Inclusion Criteria: * Participants must have at least 28 teeth in the cavity * Good oral and general health Exclusion Criteria: * active caries or periodontal disease * visible cracks in front teeth upper or lower * with evident malocclusion * restorations and prosthetics in teeth anterior teeth * gastroesophageal disorders * severe internal tooth discoloration (tetracycline , fluorosis or pulped teeth) * dentin exposure in anterior teeth and /or later * parafunctional habits * tooth sensitivity * whitening treatment prior to or undergoing orthodontic treatment * Furthermore, smokers, pregnant or breastfeeding women do not will be included.

Primary outcome measure(s)

Measure Degree of Tooth Sensitivity (pain) by a visual analog scale (VAS) After Tooth Whitening — immediately after the intervention, and for a period of 21 days of treatment
Experimental cannabidiol and gel (experimental group) and potassium nitrate gel (control group) can change sensitivity related to tooth whitening with hydrogen peroxide 35%. So it is necessary measure this pain. The volunteers will mark on the scale (VAS) the level (1-10) of sensitivity immediately after the intervention, and for a period of 21 days of treatment.

Trial sites (1)

Facility	City	Region	Status
Federal University of Pará School of Dentistry	Belém	Pará

More Universidade Federal do Para trials in Brazil

Effects of an Experimental Propolis Gel on Tooth Sensitivity Control and Post-bleaching Color Change: a Randomized Clinical Trial Starting soon

Efficacy of an Experimental Gel Based on Libidibia Ferrea on Post-bleaching Tooth Sensitivity Starting soon

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07027566 on ClinicalTrials.gov ↗ ← All trials in Brazil