1 dose of Beetroot juice intake: The volunteer will ingest 1 dose of beetroot juice containing 400mg of inorganic nitrate for 10 days.
Exercise: The volunteer will perform moderate aerobic exercise for 10 consultative days on a cyclergometer.
Study summary
The goal of this clinical trial is to verify the hemodynamic and biomarker responses of aerobic physical exercise and beetroot juice intake in postmenopausal women with hypertension. The main questions it seeks to answer are:
Is beetroot juice and aerobic exercise related to better hemodynamic responses in hypertensive postmenopausal women? Is beetroot juice and aerobic exercise related to better oxidative stress profile responses in hypertensive postmenopausal women?
The researchers will conduct a parallel clinical study with 10 days of intervention, in which 48 women will be randomized into 3 groups: 1) Aerobic exercise; 2) One shot of beetroot juice intake per day (400mg of NO3-); 3) Control (no intervention).
Eligibility
Sex
FEMALE
Min age
45 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Amenorrhea for at least 12 months
* Controlled hypertension
* Suitable for physical exercise
* Present a certificate proving fitness to practice physical exercise
Exclusion Criteria:
* Decompensated hypertension in stages 2 and 3
* Having a history of stroke or acute myocardial infarction
* Smoker
* Having physical problems or cardiovascular complications that prevent physical exercise
* Having a diagnosis of Diabetes Mellitus
* Using hormone therapy.
Primary outcome measure(s)
Hemodynamic responses — 11 days Volunteers will undergo blood pressure tests at the beginning, in the middle and after the 10 days of intervention. To assess blood pressure (BP), researchers will use the Dyna Mapa + Cardius® device, programmed with measurements to be taken every 20 min. Together with this device, the volunteers filled out a daily record of activities such as sleep, work, food, or any event that could interfere with BP or measurements. In a standardized manner, the device was set at 7 a.m., and measurements were considered valid when 24h of monitoring were obtained. Resting BP was measured with the same device after 15 min of rest in a sitting position, and for the analysis of the pressure curve, time 0 was adopted when the monitor was placed. Sytolic BP, diastolic BP, and mean BP in periods of awake, sleep and 24 h were analyzed.
Trial sites (1)
Facility
City
Region
Status
FAEFI
Uberlândia
Minas Gerais
More Federal University of Uberlandia trials in Brazil
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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