Ireland
--:--IST
Recruiting Observational

International Rare Brain Tumor Registry

NCT05697874 · tracked via the Priya Life Science Brazil tracker
Sponsor
Children's National Research Institute
Phase
Observational
Started
2023-01-01
Last updated
2026-08-07

Condition(s) studied

AstroblastomaBCOR ITD SarcomaCNS SarcomaUnclassified Tumor, Malignant

Study summary

The objective of the International Rare Brain Tumor Registry (IRBTR) is to better understand rare brain tumors through the collection of biospecimens and matched clinical data of children, adolescents, and young adult patients diagnosed with rare brain tumors.

Eligibility

Sex
ALL
Min age
—
Max age
45 Years
Healthy volunteers
No
Inclusion Criteria: * Patients with a known or suspected CNS Sarcoma. * Patients with a known or suspected BCOR-altered brain tumor * Patients with a known or suspected Astroblastoma/NM-1 altered brain tumor * Patients with known or suspected histologically ambiguous/unclassifiable brain tumor * Patients with a known or suspected rare brain tumor. * Signed informed consent by patient/ parent or guardian (assent where applicable) to participate in the study. Exclusion Criteria: * The patient has an extra-CNS primary tumor. * The patient is older than 46 years of age at diagnosis. * The patient or family is not willing to participate or does not sign informed consent.

Primary outcome measure(s)

  • Event-free Survival — 10 years
    The primary outcome measure will be time from diagnosis to an event, defined as the occurrence of progression or recurrence of the disease, occurrence of a second malignant neoplasm, or death from any cause. Each cohort will be analyzed separately.

Trial sites (13)

FacilityCityRegionStatus
Children's Hospital Los Angeles Los Angeles California Recruiting
University of California San Francisco San Francisco California Recruiting
Children's National Hospital Washington D.C. District of Columbia Recruiting
Ann & Robert H. Lurie Children's Hospital of Chicago Chicago Illinois Recruiting
Akron Children's Hospital Akron Ohio Recruiting
Cincinnati Children's Hospital Medical Center Cincinnati Ohio Recruiting
TUCCA - Santa Marcelina São Paulo São Paulo Recruiting
HOMI - Fundación Hospital de la Misericordia Bogotá Bogota D.C. Recruiting
Clinica Del Country Bogotá Colombia Recruiting
Rambam Health Care Campus Haifa Israel Recruiting
Schneider Children's Medical Center- CLALIT Health Services Petah Tikva Israel Recruiting
Dana-Dwek Children's Hospital- Tel Aviv Medical Center Tel Aviv Israel Recruiting
The Sheba Medical Center Tel HaShomer Israel Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05697874 on ClinicalTrials.gov ↗ ← All trials in Brazil