Cardiovascular Responses to Exercise in People Living With HIV/AIDS: Effects of Exercise Training

Condition(s) studied

Investigational drug(s) / intervention(s)

Exercise training: Exercise training performed during 12 weeks, 3 sessions per week of 60 minutes of strength and aerobic exercises.

Study summary

Patients living with HIV (PLWHIV) have compromised muscle metaboreflex, which can cause exercise intolerance. This randomized controlled clinical trial will verify the effects of regular exercise on autonomic and hemodynamic responses to muscle ergoreflex activation in these patients. PLWHIV without regular physical exercise will be randomly assigned into an exercise training or a control group. The exercise training group will undergo regular physical exercise during 12 weeks (60-min session performed 3 times/wk with moderate intensity), while the control group will keep inactive. Another group consisted of inactive HIV-uninfected group will be included. The primary endpoints will be blood pressure and autonomic markers in response to the Stroop Color-Word Test and the activation of muscle ergoreflex, by means of the post-exercise circulatory arrest (PECA), which will be performed with and without the topical application of a capsaicin-based analgesic balm. Secondary endpoints will include heart rate, peripheral vascular resistance, stroke volume, cardiac output, blood lactate concentration, anthropometrics, and handgrip strength. The active and inactive PLWHIV groups will be evaluated before and after the exercise training, while the healthy group only at baseline.

Eligibility

Primary outcome measure(s)

• Change from Baseline Blood Pressure at 3 months — Baseline and 3 months of follow-up
  Blood pressure will be assessed by a digital sphygmomanometer.
• Change from Baseline Heart Rate Variability at 3 months — Baseline and 3 months of follow-up
  Heart rate variability will be assessed by a heart rate monitor.

Trial sites (1)

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