Bone Density and Vascular Calcifications Evolution After Renal Transplant

Condition(s) studied

Investigational drug(s) / intervention(s)

High-resolution peripheral quantitative CT scanner (HRpQCT): HR-pQCT images of the distal radius and distal tibia (non-dominant, non-fractured limb) will be obtained using the XtremeCT device with standard protocols. HR-pQCT images wil be analysed with standard software and extended cortical measures software. This software identifies the periosteal and endosteal boundaries, enabling assessment of cortical micro- structural bone properties, including apparent cortical thickness (Ct.Th, mm), cortical tissue mineral density (TMD, mgHA/cm3) and cortical porosity (Ct.Po, %).

Study summary

The investigators project is based on:

* Assessment of bone architecture by high resolution peripheral scanner (HRpQCT) and bone densitometry (DEXA);
* The non-invasive detection of vascular calcifications (by abdominal CT scanner) and bone abnormalities associated with kidney transplantation, as well as the analysis of evolution over time;
* Longitudinal evaluation of nephrological clinical parameters (glomerular filtration rate, number and type of rejections, immunosuppressive medications) as well as biological and urinary parameters of mineral metabolism (parathormone, sclerostin, bone alkaline phosphatase) depending on the type and severity of bone abnormalities;
* The evaluation of these nephrological clinical parameters and of the biological parameters of mineral metabolism depending on the extent and evolution of vascular calcifications but also on bone morphology;
* The study of possible relationships between bone mass and muscle mass (and functioning)

Eligibility

Primary outcome measure(s)

• Bone density evolution — At 1 year
  Evolution of bone density after kidney transplantation
• Bone density evolution — At 2 year
  Evolution of bone density after kidney transplantation
• Bone micro-architecture evolution — At 1 year
  Bone micro-architecture evolution evaluate by HRpQCT after kidney transplantation
• Bone micro-architecture evolution — At 2 year
  Bone micro-architecture evolution evaluate by HRpQCT after kidney transplantation

Trial sites (1)

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