PRF With Topical Antibiotics or Antiseptics in Chronical Wounds Version 1.4

NCT02652169 · tracked via the Priya Life Science Austria tracker

Sponsor

Medical University of Vienna

Phase

Not applicable

Started

2014-06

Last updated

2022-04-07

Condition(s) studied

Chronic Skin Ulcer

Investigational drug(s) / intervention(s)

PRF mixed with amikacin and teicoplaninPRF mixed with PHMB plus MacrogololPRF plus normal salineSilver gauze

PRF mixed with amikacin and teicoplanin: PRF, mixed with amikacin and teicoplanin is applied to the chronic ulcer

PRF mixed with PHMB plus Macrogolol: PRF, mixed with Lavasorb is applied to the chronic ulcer

PRF plus normal saline: PRF as a monosubstance plus sodium chloride 0.9% is applied to the chronic ulcer

Silver gauze: Acticoat 7 silver wound dressing is applied to the chronic ulcer

Study summary

Platelet rich fibrin (PRF) is a new therapy option for chronic wounds with yet unproven therapeutic efficacy. This randomised controlled trial aims to provide evidence of the efficacy of PRF as monotherapy as well as a growth promoting carrier matrix for antimicrobial compounds. The investigators therefore designed a four armed trial with three PRF arms which are compared to each other as well as to an active comparator. The treatment arms are as follows:

Study arm 1: PRF with amikacin and teicoplanin Study arm 2: PRF with placebo (0.9% sodium chloride) Study arm 3: PRF with PHMB (polyhexanid) plus Macrogolol (Lavasorb®) Study arm 4: Acticoat 7® wound dressing as active control Patients with infected chronic wounds may be included in this trial. Infection shall be diagnosed by an experienced senior infectious diseases specialist. Patients with untreated peripheral vascular occlusive disease as defined by an ABI (ancle brachial index) of \< 0,7 are excluded from the trial as are patients with an uncontrolled diabetes mellitus or patients who have not received sufficient treatment for a diabetic foot syndrome. Any underlying illness will be treated following standard of care. In case of chronic venous insufficiency four-layered compression bandages will be applied each visit if tolerated by the patient. Alternatively compression stockings (Class III) are permitted. This is mentioned as "Disease specific treatment" in the protocol.

Patients will receive treatment for 56 days. After 28 and 56 days the wound surface will be compared to the baseline. Infection parameters (c-reactive protein and leucocyte count) will be measured weekly. Evaluation of systemic antimicrobial therapy will be performed at each visit. Systemic antimicrobial therapy is started at the discretion of a senior infectious diseases specialist.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Males and females aged over 18 who are able to give informed consent * Chronic venous ulcer with localized non-systemic soft-tissue infection diagnosed by senior infectious diseases specialist based on US FDA Guidance for Industry Chronic cutaneous ulcer and burn wounds June 2006: * slough and necrotic tissue * exsudate * smell * inflammation * presence of granulation tissue * pain * Wound size ≥ 5 cm2 and \< 200 cm2 Exclusion Criteria: * Non-treated diabetes mellitus, HbA1c \> 12 mg/dl * Non treated (orthopaedic shoe) diabetic foot syndrome * ABI \< 0,7 * Wound size 15 cm2 and \> 200 cm2 * CRP \> 5 mg/dl * Leucocytes \> 15.000 /μl * Infection of another site * Infection of the ulcer with a pathogen with inherent resistance to amikacin and teicoplanin * Known osteomyelitis * Known erysipelas * Known phlegmon * Complicated deep tissue infection not solely treatable with PRF plus antimicrobial therapy in the opinion of a senior infectious diseases specialist * Planned systemic antimicrobial therapy * Active viral hepatitis (A/B/C) or active HIV infection or active syphilis * Increased sensitivity to amikacin or teicoplanin, PHMB or macrogolol * Increased sensitivity to tramexanic acid or batroxobin * Presence of neoplastic growth in the ulcer * Thrombocytopenic patients (\<150.000 G/L) * Haemoglobin \< 95 g/L * Known pregnancy or lactation * Severe renal impairment (creatinine clearance \<30 ml/min) * History or clinical signs of impairment of the cochlea or vestibularis system * Neuromuscular diseases (i.e. Myasthenia gravis, Parkinson's disease) * Aminoglycoside treatment less than four weeks before inclusion * Other reasons opposing the study participation on the discretion of the investigators

Primary outcome measure(s)

reduction in wound area — day 56

Trial sites (1)

Facility	City	Region	Status
Medical University of Vienna	Vienna	Austria	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT02652169 on ClinicalTrials.gov ↗ ← All trials in Austria