Evaluation of the Effects of Injectable Platelet-Rich Fibrin and Hyaluronic Acid Treatments, Administered in Addition to Free Gingival Graft Therapy, on Clinical Healing.

NCT07804888 · tracked via the Priya Life Science Turkey tracker

Sponsor

Saglik Bilimleri Universitesi

Phase

Not applicable

Started

2026-09

Last updated

2026-09-04

Condition(s) studied

Lack of Keratinized TissueMucogingival SurgeryGingival Recession

Investigational drug(s) / intervention(s)

Free gingival graftFree Gingival Graft with i-PRFFree Gingival Graft with Hyaluronic Acid

Free gingival graft: The free gingival graft is obtained from the palatal donor site (1-1.5 mm thickness) and directly applied and sutured to the recipient site without any additional biological agents.

Free Gingival Graft with i-PRF: The free gingival graft is obtained from the palatal donor site (1-1.5 mm thickness) and hydrated in injectable platelet-rich fibrin (i-PRF) before fixation at the recipient site. i-PRF is prepared by centrifuging the patient's venous blood at 2500 rpm for 3 minutes.

Free Gingival Graft with Hyaluronic Acid: The free gingival graft is obtained from the palatal donor site (1-1.5 mm thickness) and soaked in 0.8% hyaluronic acid (HA) gel before fixation at the recipient site.

Study summary

The purpose of this clinical trial is to evaluate the effects of injectable platelet-rich fibrin (i-PRF) and hyaluronic acid (HA) gel on clinical healing and graft shrinkage when used in addition to Free Gingival Graft (FGG) surgery. The study involves patients with gingival recession and insufficient keratinized tissue. Participants will be randomly divided into three groups: FGG with i-PRF application, FGG with HA gel application, Conventional FGG alone (Control group). The main goal is to compare the amount of graft shrinkage and evaluate clinical wound healing parameters between these groups over a 3-month follow-up period.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Individuals aged 18 years or older. * Systemically healthy patients with no contraindications for periodontal surgery. * Patients presenting with gingival recession and/or inadequate width of keratinized tissue requiring Free Gingival Graft (FGG) therapy. * Non-smokers. * Patients who provide written informed consent to participate in the study. Exclusion Criteria: * Patients with systemic diseases that may affect wound healing (e.g., uncontrolled diabetes mellitus, autoimmune disorders). * Pregnant or lactating individuals. * Patients with poor oral hygiene. * Current smokers or tobacco users. * Patients who have received periodontal surgery in the designated surgical area within the last 6 months.

Primary outcome measure(s)

Percentage of Graft Shrinkage — Baseline, 1 month, and 3 months post-operation
Graft shrinkage will be evaluated by calculating the surface area of the graft in square millimeters using standardized clinical photographs and ImageJ software. The percentage of shrinkage is calculated with the formula: ((Immediate post-operative graft area - Follow-up graft area ) / Immediate post-operative graft area) x 100.

Trial sites (1)

Facility	City	Region	Status
University of Health Sciences, Gülhane Faculty of Dentistry	Ankara	Turkey (Türkiye)

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07804888 on ClinicalTrials.gov ↗ ← All trials in Turkey