Intraoperative Oxygenation and Pulmonary Mechanics
Study summary
This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation. Magnesium sulfate has been reported to have potential bronchodilatory and anti-inflammatory properties, which may improve gas exchange and respiratory mechanics during lung isolation.
In this study, patients who receive magnesium sulfate as part of standard anesthetic management will be compared with those who do not receive the drug. Oxygenation parameters, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. The findings of this study may help clarify whether magnesium sulfate provides measurable respiratory benefits during one-lung ventilation.
Eligibility
Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
Adults aged 18 to 80 years Scheduled for elective thoracic surgery performed with video-assisted thoracoscopic surgery (VATS) requiring one-lung ventilation under general anesthesia.
ASA physical status II-III Ability to provide informed consent Undergoing general anesthesia with double-lumen tube placement
Exclusion Criteria:
* Patients undergoing pneumonectomy
* Patients with renal, hepatic, or cardiovascular failure
* Patients with a BMI \< 15 kg/m² or \> 35 kg/m²
* Patients with a preoperative pulmonary function test showing FEV₁ \< 1.5 liters
* Patients who are transferred to the intensive care unit intubated in the postoperative period
* Patients with physical or mental conditions that prevent the performance of pulmonary function testing factors
Primary outcome measure(s)
Change in Intraoperative Oxygenation (PaO₂/FiO₂ Ratio) — From induction of anesthesia to the end of one-lung ventilation (approximately 2-3 hours) The PaO₂/FiO₂ ratio will be measured to evaluate intraoperative oxygenation during the surgery. Measurements will be recorded after induction of anesthesia (baseline) and at predefined intraoperative time points. The primary outcome is the change in PaO₂/FiO₂ ratio between baseline and intraoperative measurements in patients receiving magnesium sulfate versus control.
Trial sites (1)
Facility
City
Region
Status
Marmara University Faculty of Medicine, Basibuyuk Campus
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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