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Clinical Trials in Taiwan / NCT07307989
Recruiting Phase 2

Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis

NCT07307989 · tracked via the Priya Life Science Taiwan tracker
Sponsor
Chang Gung Memorial Hospital
Phase
Phase 2
Started
2025-08-01
Last updated
2025-12-30

Condition(s) studied

Ischemic StrokeHypercholesteremia

Investigational drug(s) / intervention(s)

statin + ezetimibe →Statin monotherapy (rosuvastatin or atorvastatin) →

statin + ezetimibe: Moderate-intensity statin plus ezetimibe 10mg

Statin monotherapy (rosuvastatin or atorvastatin): Moderate- or high-intensity statin monotherapy

Study summary

This study will be conducted at six medical institutions in Taiwan, recruiting patients who visit neurology outpatient clinics or are hospitalized within 30 days after an ischemic stroke.

Participants will be randomly assigned to either the experimental group (moderate-intensity statin plus ezetimibe) or the control group (moderate- or high-intensity statin).

Research assistants will screen patients aged 40 or older who have had an ischemic stroke or transient ischemic attack within 30 days, have atherosclerosis, and have LDL-C levels ≥100 mg/dL. Eligible cases will be reviewed by the attending physician. With physician approval, patients will be invited to join the study, and those who agree and sign informed consent will be enrolled.

Eligibility

Sex
ALL
Min age
20 Years
Max age
100 Years
Healthy volunteers
No
Inclusion Criteria: * (1) clinical diagnosis of ischemic stroke or TIA; (2) Stroke or TIA symptoms and randomized within 30 days, then taking assigned medication within 2 days of randomization; (3) aged 20 years or older; (4) LDL-C ≥ 100 mg/dL after index ischemic stroke or TIA; (5) having evidence of atherosclerosis. Exclusion Criteria: * (1) end stage renal disease because there is no clear benefit of LDL-C lowering therapy in these patients; (2) history of statin intolerance; (3) history of ezetimibe intolerance; or (4) ALT \> 100 U/L.(5) Statins were regularly used before stroke. (6) Ezetimibe was used before stroke.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Chang Gung Memorial Hospital, Chiayi Branch Pozi Taiwan Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07307989 on ClinicalTrials.gov ↗ ← All trials in Taiwan