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Clinical Trials in Taiwan / NCT07195968
Enrolling by invitation Observational

Comparative Analysis of NTG-Pd/Pa and Saline-Pd/Pa (CANS)

NCT07195968 · tracked via the Priya Life Science Taiwan tracker
Sponsor
National Taiwan University Hospital
Phase
Observational
Started
2025-09-17
Last updated
2025-09-29

Condition(s) studied

Coronary Artery Disease

Investigational drug(s) / intervention(s)

NTG-Pd/Pa measurementSaline-Pd/Pa measurement

NTG-Pd/Pa measurement: The coronary artery with intermediate stenosis will sequentially undergo NTG-Pd/Pa, saline-Pd/Pa, and FFR assessments. Intracoronary NTG dosage will follow the protocol based on blood pressure.

Saline-Pd/Pa measurement: The coronary artery with intermediate stenosis will sequentially undergo NTG-Pd/Pa, saline-Pd/Pa, and FFR assessments. Ten millilitres of intracoronary saline will be given over five seconds.

Study summary

The goal of this observational study is to compare the value of NTG-Pd/Pa and saline-Pd/Pa in participants with intermediate stenosis of the coronary artery. The main questions it aims to answer are:

The numerical difference between NTG-Pd/Pa and saline-Pd/Pa To compare the diagnostic performance of NTG-Pd/Pa and saline-Pd/Pa in predicting the binary result of FFR assessment?

Participants will undergo NTG-Pd/Pa, Saline-Pd/Pa, and FFR successively in the target vessel.

Eligibility

Sex
ALL
Min age
21 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Participants with coronary artery with 50-90% stenosis. * In participants who suffered from ST elevation myocardial infarction within 5 days, only the non-culprit vessel was eligible for coronary functional testing. Exclusion Criteria: * Systolic blood pressure is less than 90 mmHg for more than 5 minutes during examination. * Resting heart rate is less than 50 beats per minute. * Heart failure remains decompensated at the time of examination, such as inability to lie flat or cardiogenic shock. * Acute onset of asthma or chronic obstructive pulmonary disease.

Primary outcome measure(s)

Trial sites (3)

FacilityCityRegionStatus
National Taiwan University Hospital Hsin-Chu Hospital Hsinchu Select
Miaoli General Hospital, Ministry of Health and Welfare Miaoli Taiwan
Taichung Veterans General Hospital Taichung Taiwan

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07195968 on ClinicalTrials.gov ↗ ← All trials in Taiwan