iTBS in MCI and Mild AD

NCT06670820 · tracked via the Priya Life Science Taiwan tracker

Sponsor

National Defense Medical Center, Taiwan

Phase

Not applicable

Started

2024-10-31

Last updated

2024-11-01

Condition(s) studied

Mild Cognitive Impairment (MCI)Mild Alzheimer Disease

Investigational drug(s) / intervention(s)

Active rTMSSham rTMS

Active rTMS: iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total10 sessions

Sham rTMS: sham iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total 10 sessions

Study summary

This study aims to examine the effects of iTBS on cognitive function in individuals with MCI or mild AD, with a secondary objective of exploring prefrontal TBS mechanisms for cognitive function and the effect of iTBS on BDNF.

Eligibility

Sex

ALL

Min age

50 Years

Max age

85 Years

Healthy volunteers

Inclusion Criteria: * Clinical diagnosis of MCI (overall Clinical Dementia Rating of 0.5) * Clinical diagnosis of mild Alzheimer's Disease (overall Clinical Dementia Rating of 0.5 or 1) Exclusion Criteria: * History of stroke * History of uncontrol seizure * History of significant head trauma followed by persistent neurologic deficit or known structural brain abnormality * Mental illness * Drug abuse

Primary outcome measure(s)

Changes in neurocognitive function test scores (Mini-Mental State Examination；MMSE) between T1 (Day 1) and T2 (Day 14), and the differences between the experimental and control groups. — MMSE will be controlled at baseline before active or sham rTMS, 2 weeks after active and sham rTMS, 3 months after the last treatment
The mini-mental state examination (MMSE) test is a 30-point questionnaire that is used extensively in clinical and research settings to measure cognitive impairment.The MMSE is a standardized cognitive screening test with a possible score of 0-30. Any score of 24 or more (out of 30) indicates a normal cognition. Below this, scores can indicate severe (≤9 points), moderate (10-18 points) or mild (19-23 points) cognitive impairment.

Trial sites (1)

Facility	City	Region	Status
Tri-Service General Hospital	Taipei	Other

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06670820 on ClinicalTrials.gov ↗ ← All trials in Taiwan