Prebiotic Effects of Mulberry Fruit in Children and Adolescents With Atopic Dermatitis

Inclusion Criteria: * Aged 6 years and above (including 6 years) to less than 18 years (excluding 18 years) * The legal guardian has the ability to understand and is willing to sign the written informed consent document * Diagnosed by a physician according to the international Hanifin \& Rajka criteria for atopic dermatitis, with a confirmed diagnosis of more than six months Exclusion Criteria: * Allergic to berries, mulberries, fruits from the same family (such as figs), or similar chemical or biological components * Patients with immunodeficiency, including congenital or acquired immune disorders * Patients with immune-related diseases other than allergies, asthma, or allergic rhinitis, including malignancies, rheumatic diseases, lupus erythematosus, chronic liver diseases, cirrhosis, kidney diseases, diabetes, or asplenia * Individuals with other diseases or mental disorders that prevent them from complying with the intervention plan * Patients with Short Bowel Syndrome * Received oral or injectable antibiotics in the past month * Received immunomodulators, biologics, or oral/injectable steroids exceeding 2 mg/kg/day in the past three months * Underwent major surgery within 28 days before the study intervention (including the 28th day) or have not recovered from the side effects or complications of drug treatment/surgery from four weeks prior * Currently participating in other drug intervention studies * Currently experiencing systemic infection or unexplained fever (ear temperature greater than or equal to 38°C) * Pregnancy * Premature infants (born before 37 weeks, excluding 37 weeks) * Individuals with congenital diseases, nutritional or metabolic disorders, or keratinization disorders * Diagnosed with malignancies within the past five years.