Continuous passive motion device (CPM) of ankle - fastContinuous passive motion device (CPM) of ankle - slow
Continuous passive motion device (CPM) of ankle - fast: Continuous passive motion device (CPM) of ankle at 1HZ(60rpm) for 10 repetitions
Continuous passive motion device (CPM) of ankle - slow: Continuous passive motion device (CPM) of ankle 0.25HZ (15rpm) for 10 repetitions
Study summary
Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements. Spasticity is characterized by a velocity-dependent increase in stretch reflexes, accompanied by exaggerated tendon responses, while rigidity is marked by consistent resistance throughout the range of motion, traditionally considered independent of stretch velocity. However, recent studies suggest that rigidity may also be influenced by stretch velocity. This study aims to investigate muscle tone by examining spasticity, rigidity, and normal muscle function through neural and biomechanical changes. Standard clinical tools, such as the Modified Ashworth Scale and Unified Parkinson's Disease Rating Scale, along with additional assessments like the Myoton and Post-Activation Depression (PAD), will be employed.
Eligibility
Sex
ALL
Min age
20 Years
Max age
—
Healthy volunteers
Accepted
Health subjects:
Exclusion Criteria:
1. Musculoskeletal injuries on legs.
2. Osteoporosis.
SCI subjects:
Inclusion Criteria 1. Participants with chronic spinal cord injury, with injury duration greater than one year.
Exclusion Criteria
1. Current musculoskeletal or joint injuries in the lower limbs.
2. History of central or peripheral neuromuscular diseases.
3. Presence of a pacemaker.
4. Current use of antispastic or antidepressant medications.
5. Current venous thromboembolism or osteoporosis.
6. Impairment of the soleus H-reflex arc.
PD subjects:
Inclusion Criteria:
\- Clinical diagnosis of Parkinson disease.
Exclusion Criteria:
1. Musculoskeletal injuries on legs
2. Osteoporosis.
3. Any peripheral or central nervous system injury or disease patients.
Primary outcome measure(s)
H-reflex Amplitude — Before CPM, immediately after CPM The peak-to-peak amplitude of the H-reflex measured in the soleus muscle to assess spinal motor neuron excitability. Unit: Millivolts (mV)
M-wave Amplitude — Before CPM, immediately after CPM The peak-to-peak amplitude of the M-wave recorded in the soleus muscle to assess peripheral motor neuron excitability and muscle response. Unit: Millivolts (mV)
Level of Post-Activation Depression (PAD) of the H-reflex. — Before CPM, immediately after CPM The H-reflex will be elicited by electrical stimulation of the tibial nerve (or other motor nerves), and PAD will be assessed by measuring the reduction in H-reflex amplitude following a series of repetitive stimuli. The amplitude of the H-reflex after repeated stimulation will be compared to the baseline single stimulus.
H/M ratio — Before CPM, immediately after CPM The H/M ratio is calculated by dividing the amplitude of the H-reflex by the amplitude of the M-wave.
Muscle Tone (Frequency, Hz) — Before CPM, immediately after CPM This parameter measures the natural oscillation frequency of the muscle in response. It reflects the muscle's state of tension or readiness
Elasticity (Dynamic Stiffness, N/m) — Before CPM, immediately after CPM Elasticity, measured in Newtons per meter, reflects the muscle's ability to return to its original shape after being deformed by the impulse
Stiffness (Decay, ms) — Before CPM, immediately after CPM This parameter quantifies the rate at which the muscle returns to its initial state after the impulse, indicating the muscle's stiffness.
Mechanical Stress (Creep, s) and Relaxation (S) — Before CPM, immediately after CPM These parameters measure the time it takes for muscle tissue to adapt to a sustained force (creep) and the time it takes for the muscle to return to a relaxed state after removing the force (relaxation)
Plantar foot pressure distribution and peak pressure — Measured continuously during CPM Foot pressure will be measured using a pressure sensors during ankle movement.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.
