The goal of this observational study is to assess the relationship between female hormonal status and postoperative wound healing in reduction mammaplasty. The main questions it aims to answer are:
1. Does wound healing differ depending on whether the operation takes place before or after ovulation in the menstrual cycle?
2. Does estradiol have a positive effect on wound healing?
Participants with mammary hypertrophy will undergo reduction mammaplasty, and the investigators will measure their hormonal profile (LH, FSH, and estradiol) on the day of surgery.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Symptomatic breast hypertrophy
* Premenopausal
Exclusion Criteria:
* Previous breast reduction surgery
* Menopausal status
* Oral contraceptives
* Corticosteroid therapy
* History of breast cancer
* Active smoking and use of nicotine substitution products
Primary outcome measure(s)
Wound healing at 21 days postoperative — 21 days Complete wound healing at day 21 will be evaluated in all patient groups and correlated with serum estradiol levels measured on the day of surgery. At this time point, complete healing is defined as a closed, fully epithelialized scar with only mild residual inflammation and no need for further dressings. Persistent crusting, discharge, or dehiscence exposing dermis or subcutaneous tissue will be classified as delayed healing and managed with continued dressing care. For consistency, "complete healing" is operationally defined as a wound that no longer requires any dressing and can remain exposed to air, and results will be documented using standardized photographs.
Trial sites (1)
Facility
City
Region
Status
University Hospital of Geneva
Geneva
Switzerland
More University Hospital, Geneva trials in Switzerland
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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