The electroencephalogram (EEG) measures brain waves during general anaesthesia via an electrode placed on the forehead. These brain waves show the different stages of natural sleep as well as the state of the brain when a patient is put under general anaesthesia for an operation. In this research project, the investigators aim to find out if the EEG signal shows slow wave activity (where an EEG wave repeats every 10 to 1 seconds) just before the onset of the burst suppression pattern, where the EEG waveform alternates between very small (suppression) and very large (burst) signals over a period of a few seconds. It is not currently known if and how often this occurs, but if it does, it would be a useful signal to help anaesthetists administer just the right dose of anaesthesia to patients.
Eligibility
Sex
ALL
Min age
60 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* patients undergoing elective general anaesthesia, and
* aged 60 or above, and
* have a good comprehension of German, and
* require a general anaesthesia length of at least 1 hour (to ensure that we can record enough good quality EEG signal).
Exclusion Criteria:
* patients undergoing head or neck surgery or surgery in prone or lateral decubitus position (due to the limited placement space on the forehead required for the two EEG electrode systems, limited access to the forehead during surgery), or
* patients undergoing emergency surgery, operations only requiring local or regional anaesthesia with sedation, or
* patients who cannot follow procedures, or have an inability to give consent, or
* known participation in another human research project (ClinO/HRO) that may affect the objectives of this study.
Primary outcome measure(s)
Slowwave Peak Amplitudes prior to Burst Suppression — This outcome is measured during the anesthesia for surgery, i.e., between when a patient is anaesthetised until they wake up following the operation, all on the same day. The primary variables of interest are peak amplitudes in the slow wave signal and absolute power in the EEG frequency spectra when recorded from immediately prior to the onset of burst suppression.
Trial sites (2)
Facility
City
Region
Status
Hirslanden Clinic Aarau
Aarau
Aagrau
Cantonal Hospital of Aarau
Aarau
Canton of Aargau
More Insel Gruppe AG, University Hospital Bern trials in Switzerland
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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