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Clinical Trials in Switzerland / NCT06905470
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The Effects of Eccentric Compared to Standard Strength Training in Primary Spinal Cord Injury Rehabilitation

NCT06905470 · tracked via the Priya Life Science Switzerland tracker
Phase
Not applicable
Started
2026-12
Last updated
2026-09-28

Condition(s) studied

Spinal Cord Injury

Investigational drug(s) / intervention(s)

Eccentric (KREHA) trainingStandard clinical routine strength (STAN) training

Eccentric (KREHA) training: 20 eccentric resistance training sessions will be performed on a symmetric arm-crank ergometer in a supine position.

Standard clinical routine strength (STAN) training: The regular strength training intervention consists of a total of 20 training sessions at the gym of the study center, performed following clinical routine procedures.

Study summary

The goal of this clinical trial is to assess the effects of eccentric arm-crank (KREHA) training compared to standard clinical routine strength (STAN) training in individuals undergoing primary spinal cord injury (SCI) rehabilitation.

The main questions this trail aims to answer are:

* what are the effects of the training on upper body strength, aerobic performance, muscle volume, functional independence, and health-related quality of life?
* is the KREHA training feasible to implement into the rehabilitation routine?

Participants will:

* perform either 20 KREHA sessions or 20 STAN sessions within 12 weeks
* perform a test battery to collect data on training effects before (pretest) and after (posttest) the study intervention

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * 18 years or older. * informed consent as confirmed per signature. * traumatic or disease-related SCI. * participating in the routine strength training program during primary SCI rehabilitation at the study center (generally this is initiated around one month after SCI onset). * wheelchair dependency during activities of daily living, defined by a score of 0-2 in the SCIM subsection regarding "Mobility in the house". * passed sports medical assessment and having sufficient biceps/triceps function to perform arm-crank training, as determined by an experienced sports medicine physician Exclusion Criteria: * inflammatory or neurodegenerative diseases (including multiple sclerosis or Guillain-Barré syndrome). * comorbidities or other health issues that may interfere with study participation, inability or contraindications to undergo the investigated intervention. * MRI contraindications (magnetic metal parts or electronic implants such as pacemakers in the body). * pregnancy (anamnestic).

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Swiss Paraplegic Centre Nottwil Canton of Lucerne

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06905470 on ClinicalTrials.gov ↗ ← All trials in Switzerland