Glaucoma, Open-AngleExercise TrainingMicrovascular Health
Investigational drug(s) / intervention(s)
Exercise TrainingLifestyle Counselling
Exercise Training: 6-months supervised exercise training + 6 months unsupervised exercise training
Lifestyle Counselling: 12-months of lifestyle counselling
Study summary
HIT GLAUCOMA is a multicenter exercise study for glaucoma patients between three institutes: the Department of Sport, Exercise and Health (DSBG) of the University of Basel, the Eye Clinic at the University Hospital Basel and the UZ Leuven (Belgium). The main objective of the study is to investigate the possibility of using exercise therapy to treat glaucoma. Participants will be randomly divided into two groups: Intervention and Control group. The intervention group will receive a high-intensity interval training plan, and the control group will receive lifestyle counseling and standard therapy. With this method, the study aims to validate an exercise therapy concept that could significantly improve disease progression and quality of life in patients with glaucoma.
Eligibility
Sex
ALL
Min age
40 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
* Voluntary written informed consent of the participant has been obtained prior to any screening procedures
* Patients with primary open angle glaucoma (POAG), high tension glaucoma (HTG) and normal tension glaucoma (NTG), aged 40 - 75 years
* In regular follow-up in either of the two study centres
Exclusion Criteria:
* Patients having had glaucoma surgery within 6 months before start of the project
* Patients with changes in topical medication or laser trabeculoplasty within 3 months before start of the project
* Patients with very severe glaucoma (visual field mean deviation lower than -12Db)
* Significant opacification of ocular media
* Patients with life-threatening arrhythmia, signs of ischemia during CPET which preclude participation in an exercise trial
* Patients with insulin treated diabetes, chronic obstructive pulmonary disease or cancer.
* Patients doing ≥1 structured exercise training session per week or \>150min of exercise/week assessed via the following two questions: a. On average, how many days per week do you engage in moderate to vigorous physical activity (like brisk walking)? b. On average, how many minutes per day do you engage in physical activity at this level? Calculate the total weekly minutes of exercise by multiplying a times b.
* Mental or physical limitation precluding participation in a high intensity exercise program
Primary outcome measure(s)
Microvascular health: retinal arteriolar and venular dilation and diameters — 6-months Retinal arteriolar and venular flicker light-induced dilation after six months; Retinal arteriolar and venular diameters after six months
Trial sites (1)
Facility
City
Region
Status
University of Basel, Department of Sport, Exercise & Health
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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