Uppsala Self-Screening of Cardiovascular Health

Condition(s) studied

Investigational drug(s) / intervention(s)

Home-based multimodal cardiovascular screening: Self-administered home-based screening program: 7-day home BP, DBS biomarker self-sampling, digital questionnaire; structured digital return of results; threshold-based initiation of guideline-recommended pharmacotherapy and referral to clinical care.

Study summary

U-SCREEN is a randomized controlled trial evaluating whether systematic home-based multimodal screening for cardiovascular risk conditions, offered to residents in Region Uppsala turning 50, 55, 60, 65, 70 or 75 years of age, can identify clinically actionable cardiovascular risk factors more effectively than usual care. Participants randomized to the screening arm receive a home blood pressure measurement device, a dried blood spot sampling kit (for ApoB, HbA1c and creatinine), and a digital questionnaire. The control arm receives usual care. Recruitment runs 2024-2027 with a target identification of 10,000 cardiovascular risk conditions.

Eligibility

Primary outcome measure(s)

• Rate of total major adverse cardiovascular events over 10 years — Within 10 years after randomization
• Number of initiated guideline-recommended pharmacotherapies for cardiovascular risk factors within 12 months — Within 12 months after randomization

Trial sites (1)

Other trials for the same condition