SYSTEMS-LEVEL ANALYSES OF IMMUNE DYSREGULATION

Condition(s) studied

Investigational drug(s) / intervention(s)

Immunomodulation: Variable protocols for combined immunomodulatory therapies currently in use for different forms of immune dysregulation

Study summary

The aim of the SAID study is to create a national resource in Sweden to enable comprehensive immunological analyses of an extremely complex and clinically challenging group of individuals with variable forms of immune system dysregulation. We hope to establish a biobank of primarily blood and fecal samples from children and adults, with confirmed or suspected immune dysregulation, as well as age- and sex- matched healthy controls, for comparisons of immune cell/mediator alongside various clinical presentations of these immunological diseases as well as microbiome samples as possible a possible modifier of clinical presentations. The project will also include the establishment of a national database with deep immunological data, treatment and clinical outcomes for these patients, accessible to participating researchers and clinicians.

Eligibility

Primary outcome measure(s)

• control of immune dysregulation — 1-3 months from start of therapy
  Remission and control of immune dysregulation manifested as reduced inflammation, symptom relieve and halted immunoproliferation for examples

Trial sites (1)

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