Micronutrient and Additive Modifications May Optimize Diet To Health

Condition(s) studied

Investigational drug(s) / intervention(s)

Normal diet: These patients will be given advice about a normal healthy diet.

E400 elimination: Patients in the intervention group will be given advice how to eliminate E440 additives with regard to carragenan, CMC and polysorbates.

Study summary

This is a prospective clinical intervention trial where patients with moderately active ulcerative colitis are randomized to either normal healthy diet or a diet with elimination of emulsifying agents within the E 400-group with special respect to carragenan, CMC and polysorbates. At study start and end after one month their diet, clinical characteristics and microbiota will be analysed. The hypotheses are that their disease activity measured with calprotectin and their microbiota will improve after intervention.

Eligibility

Primary outcome measure(s)

• Calprotectin — One month
  A protein in faeces that increases when there is a flare of the colitis
• Microbiota diversity — One month
  The diversity of the GI microbiota reflects disease severity

Trial sites (1)

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