Swedish Evaluation of Left Ventricular Assist Device as Permanent Treatment in End-stage Heart Failure

Inclusion Criteria: 1. Signed informed consent 2. Adult (≥ 18 years) 3. Chronic heart failure ≥ 45 days or stable not supported by mechanical circulatory support since \>7days on single inotrope. 4. Left ventricular ejection fraction ≤ 30%. 5. NYHA IIIB-IV, INTERMACS profile 2-6 6. At least 2 of 4 adverse prognostic criteria: * SHFM estimated 1-year survival ≤75% * NTproBNP ≥ 2000 ng/l * VO2 max \< 14 ml/kg/min or \<50% of predicted VO2max with attainment of anaerobic threshold (AT), or unable to perform. * Need for continuous or intermittent inotropic support or \>2 hospitalizations during last 6 months. 7. Receiving medical management with optimal doses of betablockers, ACE-inhibitors or ARBs, and MRAs for at least 30 days if tolerated. 8. Receiving CRT if indicated for at least 45 days. 9. Receiving ICD if indicated and appropriate. 10. Ineligible for cardiac transplantation (e.g. high age and/or co-morbidities) 11. Considered suitable for the study by a multidisciplinary board Exclusion Criteria: 1. Eligible for heart transplantation or is likely to become eligible after VAD treatment (bridge-to-candidacy) 2. Indication for revascularisation, valvular surgery or other cardiac intervention expected to improve cardiac function and prognosis (CABG, PCI TAVI, mitraclip etc.) 3. INTERMACS profile 1 "crash and burn" 4. On-going mechanical circulatory support. 5. Heart failure due to restrictive cardiomyopathy pericardial disease, active myocarditis or uncorrected thyroid disease. 6. Mechanical aortic valve that will not be converted to a bioprosthesis or patch 7. Moderate to severe aortic insufficiency without plans for correction 8. Technical obstacles, which pose an inordinately high surgical risk 9. Active, uncontrolled infection 11\. Stroke within 90 days or carotid artery stenosis \> 80 % 12. Significant vascular disease. 13. Severe COPD or severe restrictive lung disease. 14. Intrinsic hepatic disease as defined by liver enzyme values (AST or ALT or total bilirubin) \> 5 times the upper limit of normal, or INR \> 2.0, which is not due to anti-coagulant therapy. 15\. Intolerance to anticoagulant or antiplatelet therapies or any other operative therapy the patient will require based upon the patient's health status. 16\. Platelet count \< 50,000. 17. Measured GFR \<20 ml/min/1.73m2 unresponsive to inotrope treatment or chronic dialysis. 18\. High risk for right ventricular failure according to echocardiography and/or invasive hemodynamic measurements as judged by the investigator (\>2 parameter constitute an exclusion criteria) using a combination of the: a. Severe TI b. TAPSE \< 0.72 cm c. RVEDD/LVEDD \> 0.72 d. CVP \> 16 mm Hg e. MPAP - RAP \< 10 mmHg SPAP-DPAP/CVPm \>1 ok, \<0.5 very bad, in between borderline f. CVP/PCWP \> 0.63 g. RVSWI \< 300 mm Hg x ml/m2 h. Bilirubin \> 34 micromol/L 19. Body Mass Index (BMI) \> 42 kg/m2. 20. Psychiatric disease, cognitive dysfunction, alcohol or drug abuse, or psychosocial issues that are likely to impair study compliance 21. Female of childbearing age with a positive pregnancy test or not willing to use adequate contraceptive precautions during the study. 22\. Condition, other than heart failure, that could limit survival to less than 2 years.