The goal of this observational study is to determine whether metabolomic profiles combined with clinical data can predict high-flow nasal cannula (HFNC) failure and help optimize respiratory support in adult patients with acute hypoxemic respiratory failure (AHRF). The main questions it aims to answer are:
Can metabolomic biomarkers identify patients at higher risk of HFNC failure? Does combining metabolomic and clinical data improve the prediction of respiratory support escalation and clinical outcomes?
Participants will:
Receive standard HFNC treatment according to clinical practice. Undergo collection of clinical, physiological, and laboratory data. Provide blood samples for metabolomic analysis during respiratory support.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Adult patients (≥18 years old).
* Admission to the intensive care unit (ICU) with acute hypoxemic respiratory failure (AHRF).
* Treatment with high-flow nasal cannula (HFNC) as the initial respiratory support strategy.
* Inclusion within the first 24 hours after HFNC initiation.
* Provision of informed consent by the patient or legally authorized representative.
Exclusion Criteria:
* Age \<18 years.
* Active do-not-resuscitate (DNR) orders or limitation of therapeutic effort.
* Refusal or inability to provide informed consent.
* Previous invasive mechanical ventilation before study inclusion.
Primary outcome measure(s)
HFNC Failure — Within the first 28 days after HFNC initiation. Failure of high-flow nasal cannula (HFNC), defined as the need for invasive mechanical ventilation in patients with acute hypoxemic respiratory failure (AHRF).
Trial sites (1)
Facility
City
Region
Status
Hospital del Mar
Barcelona
Catalonia
Recruiting
More Hospital del Mar Research Institute (IMIM) trials in Spain
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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