real tDCS and exerciseSham tDCS and exerciseExercise
real tDCS and exercise: 24 sessions of reactive exercise simulatenously with anodal tDCS over the motor cortex contralteral to the most affected side.
Sham tDCS and exercise: 24 sessions of reactive exercise with sham tDCS
Exercise: 24 sessions of reactive exercise
Study summary
A controlled, blinded, and randomized clinical study will be carried out in a large sample of people with Parkinson's disease, where the combined effects of physical exercise and transcranial direct curren stimlation (tDCS) on motor function will be evaluated.
Eligibility
Sex
ALL
Min age
—
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
Clinical diagnosis of idiopathic Parkinson's disease, established according to the UK Parkinson's Disease Society Brain Bank Criteria.
Ability to understand and comply with study procedures.
Stable antiparkinsonian medication regimen prior to study participation.
Exclusion Criteria:
Significant cognitive impairment, defined as a score \< 23 on the Mini-Mental State Examination (MMSE).
Below-average premorbid intelligence, defined as a score \< 40 on the Vocabulary subtest of the Wechsler Adult Intelligence Scale - Third Edition (WAIS-III).
Clinically significant depression, defined as a score \> 10 on the Geriatric Depression Scale (GDS-15).
Current treatment with cholinesterase inhibitors.
Presence of severe cardiovascular disease, including but not limited to:
Congestive heart failure
Ischemic heart disease
Cardiac pacemaker
Orthostatic hypotension
Uncontrolled diabetes mellitus.
History of stroke or traumatic brain injury.
History of seizure disorder or epilepsy.
Presence or prior implantation of a deep brain stimulation (DBS) device.
History of major orthopedic surgery that could interfere with motor performance or gait.
Presence of implanted electronic devices, including cardiac pacemakers, incompatible with study procedures.
Primary outcome measure(s)
Gait Speed at Preferred Speed — From enrollment to the end of treatment at 7 weeks Gait speed assessed during walking at preferred speed using the OptoGait System. Units m/s
Step length at Preferred Speed — From enrollment to the end of treatment at 7 weeks Step length assessed during walking at preferred speed using the OptoGait System. Units meters
Cadence at Preferred Speed — From enrollment to the end of treatment at 7 weeks Cadence assessed during walking at preferred speed using the OptoGait System. Units steps/min
Gait Speed at Maximal Speed — From enrollment to the end of treatment at 7 weeks Gait speed assessed during walking at maximal speed using the OptoGait System. Units m/s
Step Length at Maximal Speed — From enrollment to the end of treatment at 7 weeks Step length assessed during walking at maximal speed using the OptoGait System. Units meters
Cadence at Maximal Speed — From enrollment to the end of treatment at 7 weeks Cadence assessed during walking at maximal speed using the OptoGait System. Units steps/minute
Timed Up and Go test performance — From enrollment to the end of treatment at 7 weeks Functional mobility assessed using the Timed Up and Go (TUG) test. The outcome is defined as the time required to stand up from a chair, walk 3 meters, turn around, walk back to the chair, and sit down again.
Performance is expressed in seconds, with lower values indicating better functional mobility.
Choice stepping reaction time — From enrollment to the end of treatment at 7 weeks Choice stepping reaction time assessed using an adapted Choice Stepping Reaction Time (CSRT) test.
Participants stood on a platform and were instructed to step as quickly as possible onto one of four target devices in response to a visual stimulus.
Four electronic sensor-based devices were positioned in front of and to the side of each foot.
Participants responded using the left foot for left-side targets and the right foot for right-side targets.
Reaction time was defined as the time elapsed between stimulus onset and foot contact with the target device, recorded in milliseconds.
The outcome corresponds to the mean reaction time across 20 stimuli.
Choice arm reaching reaction time — From enrollment to the end of treatment at 7 weeks Choice arm reaching reaction time assessed using an adapted choice reaction time task.
Participants were seated and instructed to reach as quickly as possible toward one of four target devices placed on a table in response to a visual stimulus.
Targets were arranged in front of and to the side of each hand. Participants responded using the left hand for left-side targets and the right hand for right-side targets.
Reaction time was defined as the time elapsed between stimulus onset and hand contact with the target device, recorded in milliseconds.
The outcome corresponds to the mean reaction time across 20 stimuli.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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