Sex Differences in Exercise-Induced Hypoalgesia

Condition(s) studied

Investigational drug(s) / intervention(s)

Aerobic exercise using cycle ergometer: Participants will perform a 30-minute aerobic exercise protocol using a lower-limb cycle ergometer at 70% heart rate reserve. The protocol includes: * 5-minute warm-up * 20-minute exercise at target intensity * 5-minute cool-down Heart rate will be monitored continuously using a validated heart rate monitor.

Study summary

Exercise-induced hypoalgesia (EIH) refers to the reduction in pain sensitivity following acute exercise. Although aerobic exercise has been shown to induce hypoalgesia in healthy individuals, it remains unclear whether the magnitude of this response differs between men and women.

This quasi-experimental study aims to evaluate sex differences in pressure pain thresholds following a standardized aerobic exercise protocol using a lower-limb cycle ergometer. Pressure pain thresholds will be assessed before exercise, immediately after exercise, and 30 minutes after exercise in healthy adults aged 18 to 65 years.

The findings of this study may contribute to improving individualized exercise prescription strategies based on sex differences in pain modulation.

Eligibility

Primary outcome measure(s)

• Pressure Pain Threshold at Quadriceps — Pre-exercise, immediately post-exercise, and 30 minutes post-exercise
  Pressure pain threshold measured using a digital pressure algometer at the quadriceps muscle.

Trial sites (1)

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