Metabolic alterations during pregnancy have been associated with adverse maternal-fetal outcomes, including low birth weight and pregnancy complications. Maternal endothelial dysfunction, oxidative stress, insulin resistance, and placental mitochondrial dysfunction are thought to contribute to fetal metabolic disturbances. Lifestyle changes, such as structured exercise during pregnancy, may modulate maternal and placental factors.
This randomized controlled trial will evaluate the effects of a multicomponent exercise program during the second and third trimester on maternal functional capacity, vascular health, anthropometry, metabolic biomarkers, placental function, and newborn health outcomes.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
40 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Primigravid women
* Gestational age 16-20 weeks
* No severe malformations on ultrasound
* Regular prenatal care and medical clearance from obstetrician
* Being healthy and able to exercise following American College of Obstetricians and Gynecologists (ACOG) guidelines
Exclusion Criteria:
* Medical or obstetric complication excluding exercise ( ACOG guideline) Major surgery or trauma in past year
* Cancer diagnosis
* Cervical incompetence
* History of ≥2 spontaneous abortions
* Multiple pregnancy
* Vaginal bleeding, placenta previa, or threatened abortion
* COPD, asthma, or chronic bronchitis
* Renal, musculoskeletal, cardiovascular, or systemic infections limiting exercise
* Polyhydramnios or oligohydramnios
* Not availability to attend to the physical exercise program
Primary outcome measure(s)
Cardiorespiratory fitness (Vo2max) — at the 16th and 34-36th week of gestation The modified cycle protocol will be performed to estimate maximal oxygen uptake (VO2max), and will be used as measure of cardiorespiratory fitness.
Maternal weight gain (kg) — 34-36th week of gestation Maternal weight gain will be defined as the weight change from baseline measurement to the last measurement
Trial sites (1)
Facility
City
Region
Status
Navarrabiomed, Hospital Universitario de Navarra (HUN) and Universidad Pública de Navarra (UPNA)
Pamplona
Navarre
More Universidad Pública de Navarra trials in Spain
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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