Headache (Migraine)MigraineMigraine HeadacheMigraine with AuraMigraine Without AuraEpisodic MigraineChronic Migraine HeadacheChronic Migraine, HeadacheEpisodic Migraine Headache
Investigational drug(s) / intervention(s)
Saliva test
Saliva test: Sampling of CGRP in saliva and DNA blood test and sex hormones blood test.
Study summary
Patients will be asked to visit the study center 2 times, the first time for clinical assessment and a second time for sample collection. Healthy controls will only be asked to visit the study center for sample collection. A sample of blood and saliva will be collected in order to measure CGRP levels and DNA and hormone testing.
Eligibility
Sex
ALL
Min age
6 Years
Max age
75 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Migraine patients according to ICHD-3 criteria
* Healthy controls paired to patient age and sex, without headache and without first degree family history of headache.
Exclusion Criteria:
* Presence of any major medical or neurological illness.
* Presence of any salivary gland malfunction.
* Abuse or dependence to tobacco, alcohol or any drug in the previous 12 months before the enrollment.
* Active migraine preventive treatment.
* Pregnant or breastfeeding female.
Primary outcome measure(s)
CGRP level — Through study completion, an average of 1 year Measure of CGRP in saliva
Hormone levels — Through study completion, an average of 1 year Blood test to quantify female hormones (FSH, LH, estradiol, progesterone, prolactin) and male hormones (testosterone) in all participants except for prepubertal children.
DNA test — Through study completion, an average of 1 year DNA testing for CGRP or its receptor related genes (CALCA, CALCB, CALCRL and RAMP1)
Trial sites (1)
Facility
City
Region
Status
Vall d'Hebron University Hospital
Barcelona
Barcelona
Recruiting
More Hospital Universitari Vall d'Hebron Research Institute trials in Spain
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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