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Clinical Trials in Spain / NCT04367883
Recruiting Observational

Influenza Vaccination, ACEI and ARB in the Evolution of SARS-CoV2 Infection

NCT04367883 · tracked via the Priya Life Science Spain tracker
Sponsor
Consorci Sanitari de Terrassa
Phase
Observational
Started
2020-03-01
Last updated
2026-03-25

Condition(s) studied

COVID19Influenza VaccinationACE InhibitorsARBAntihistamine AllergyAmantadine

Investigational drug(s) / intervention(s)

AntihistamineAmantadine →ACEI →ARBInfluenza vaccine and COVID

Antihistamine: No intervention is performed. We propose an observational study.

Amantadine: No intervention is performed. We propose an observational study

ACEI: No intervention is performed. We propose an observational study.

ARB: No intervention is performed. We propose an observational study.

Influenza vaccine and COVID: No intervention is performed. We propose an observational study.

Study summary

Some authors have proposed the use of the flu vaccine to reduce the severity of COVID-19 cases, while some have proposed the use of ACE Inhibitors (ACEI) or Angiotensin Receptor blockers (ARB), since this virus shares hemagglutinin as a transmission mechanism and acts on the ACE2 enzyme during infection.

Other authors described how none of the elderly patients receiving antihistamines and azythromycin in two nursing homes in Toledo -Spain- during the first wave died or needed hospital admission, even considering that 100% of residents had a positive serological test after that wave. Other authors have described a positive evolution in patients receiving amantadine for their Parkinson's disease.

The aim is to evaluate whether the admitted patients who are previously vaccinated or those who were already receiving these treatments showed a better evolution.

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Hospital Admissions at the Hospital of Terrassa from March 1, 2020 for any cause. Exclusion Criteria: * None. * For comparison of percentage of Influenza vaccination, ACEI and ARB vs general population, patients from outside the reference area of the Terrassa Health Consortium would be excluded.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Hospital de Terrassa Terrassa Barcelona Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04367883 on ClinicalTrials.gov ↗ ← All trials in Spain