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Clinical Trials in Singapore / NCT07151729
Recruiting Not applicable

Use of Anodal tDCS to Enhance Upper Limb Recovery in Stroke

NCT07151729 · tracked via the Priya Life Science Singapore tracker
Phase
Not applicable
Started
2025-09-01
Last updated
2025-09-03

Condition(s) studied

Stroke

Investigational drug(s) / intervention(s)

Anodal tDCSSham tDCS

Anodal tDCS: This anodal tDCS is applied over the contralateral dorsal premotor cortex (instead of the ipsilateral motor cortex in previous studies).

Sham tDCS: Sham tDCS is applied

Study summary

This will be a randomized, blinded, sham-controlled trial. The medical device used, Soterix Medical 1x1 tDCS stimulator, is capable of delivering either real or sham tDCS and has been used in many randomised controlled trials in stroke patients.

50 patients with subacute stroke and severe upper limb weakness within 8 weeks of stroke on transfer to TTSH stroke rehab wards will be recruited over a period of 10 months. Recruited patients will be randomized into the intervention and control arms in a 1:1 ratio.

Eligibility

Sex
ALL
Min age
21 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria: * First ever unilateral ischaemic or haemorrhagic stroke, as documented by CT or MRI scans * Age 21-80 years, both males and females * Within 8 weeks of stroke onset * Severe weakness of one upper limb, defined by a Shoulder Abduction and Finger Extension (SAFE) score \< 5 (Medical Research Council grading) * Provision of informed consent by patient or a legal guardian in accordance with the local ethics committee guidelines and the Declaration of Helsinki Exclusion Criteria: * Bilateral hemispheric or cerebellar strokes * Pre-existing arm pathology (e.g. contracture, severe pain, etc.) on the affected side * Presence of brain implants, and previous insertion of external ventricular drains. * Metallic implants at the level of the neck, mouth cavity and below are permitted (e.g. Cardiac stents, dental implants, pacemakers and other metallic objects) * A history of spontaneous seizures, epilepsy, brain tumour, and cranial surgery * Severe cognitive impairment (MOCA Score \<10) that would hinder sufficient understanding of the instructions * Pregnancy

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Tan Tock Seng Hospital - Integrated Care Hub Singapore Singapore Recruiting

More Tan Tock Seng Hospital trials in Singapore

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07151729 on ClinicalTrials.gov ↗ ← All trials in Singapore