Assessment of the Impact of Repeated Ischemic Preconditioning Episodes on Hemodynamic and Metabolic Parameters in Patients at Various Stages of Chronic Kidney Disease

Condition(s) studied

Investigational drug(s) / intervention(s)

Preconditioning with control ischemic episodes: 4 cycles of 5-minute inflation and deflation using a sphygmomanometer cuff at a pressure of 30 mmHg above the systolic value through three consecutive days

Study summary

The aim of our study is to evaluate the impact of repeated episodes of ischemic quenching on changes in blood pressure, heart rate and laboratory parameters of inflammation in patients with kidney diseases. There is credible evidence that intentionally producing periods of ischemia provides protection of the myocardium and blood vessels against subsequent ischemic injury. The examination will be performed during hospitalization in the Department of Nephrology, Hypertension, Transplantology and Internal Diseases and will last 4 days. On the first day, blood pressure will be measured using an automatic blood pressure monitor, radial artery pulse, blood saturation will be measured using a pulse oximeter, and approximately 6 ml of venous blood will be collected from the elbow bend area for laboratory tests. Then, compression of the lower limb below the knee will be performed using a blood pressure cuff. Four 5-minute cycles of inflation and deflation of the cuff will be performed. The pressure on the lower limb will be repeated on the next two days. On the last day of the examination, blood pressure, heart rate and blood saturation will be measured again, and approximately 6 ml of venous blood will be collected again for laboratory tests.

Eligibility

Primary outcome measure(s)

• Assessment of changes of parameter: Measurement of SIRT-1 [ng/] — 7 days
  Measurement of SIRT-1 \[ng/\] at the beginning and 7 days
• Assessment of changes of parameter blood saturation [%]. — 7 days
  at the beginning and 7 days
• Assessment of IL-6 — 7 days
  Measurement of IL-6 \[ng/ml\] at the beginning and 7 days.
• Assessment of Blood pressure — 7 days
  Blood pressure \[mmHg\] will be checked at the beginning and 7 days
• Assessment of heart beat/min — 7 days
  will be checked at the beginning and 7 days

Trial sites (2)

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