Phacoemulsification With Intraocular Lens Implantation and Deep SclerectomyPhacoemulsification With Intraocular Lens Implantation
Phacoemulsification With Intraocular Lens Implantation and Deep Sclerectomy: Standard-of-care combined cataract surgery (phacoemulsification with intraocular lens implantation) performed together with deep sclerectomy for glaucoma management. Intraoperative collection of aqueous humor and routinely removed ocular tissues (such as sclera and anterior lens capsule) is performed for research analyses.
Phacoemulsification With Intraocular Lens Implantation: Standard-of-care cataract surgery (phacoemulsification with intraocular lens implantation). Intraoperative collection of aqueous humor and routinely removed ocular tissue (anterior lens capsule) is performed for research analyses.
Study summary
This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age ≥ 18 years.
* Scheduled for cataract surgery (phacoemulsification with intraocular lens implantation).
* Ability to provide written informed consent.
* For glaucoma arm: diagnosis of primary open-angle glaucoma (POAG) with coexisting cataract, and planned combined cataract surgery with glaucoma procedure.
* For control arm: cataract without glaucoma and without other significant ocular pathology.
Exclusion Criteria:
* Age \< 18 years.
* Pregnancy or breastfeeding.
* Advanced visual impairment in the study eye (visual aquity worse than counting fingers).
* Any glaucoma type other than primary open-angle glaucoma (e.g., angle-closure, secondary, neovascular glaucoma).
* History of intraocular surgery in the study eye (including glaucoma surgery), vitreoretinal surgery, corneal transplantation, or refractive surgery.
* Active or previous uveitis.
* Other significant chronic ocular disease in the study eye (other than cataract and POAG in the glaucoma arm).
* Inability to comply with study procedures or follow-up visits.
Primary outcome measure(s)
IOP — Through study completion, an average of 1 year Intraocular Pressure
Visual Field — Through study completion, an average of 1 year Visual Field of the mean defect (MD)
BCVA — Through study completion, an average of 1 year Best-corrected visual acuity
Protein expression — Through study completion, an average of 1 year Measured by ICP-MS/LC-MS
RNFL — Through study completion, an average of 1 year Retinal Nerve Fiber Layer (OCT)
Trial sites (2)
Facility
City
Region
Status
Military Institute of Medicine - National Research Institute
Warsaw
Poland
Recruiting
University of Warsaw
Warsaw
Poland
Recruiting
More Military Institute od Medicine National Research Institute trials in Poland
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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