Active repetitive transcranial magnetic stimulationSham repetitive transcranial magnetic stimulation
Active repetitive transcranial magnetic stimulation: High frequency rTMS over the primary motor area to induce the long term potentiation of primary motor areas for the muscles of upper extremity.
Sham repetitive transcranial magnetic stimulation: Sham stimulation to mimic the high frequency rTMS over the primary motor area.
Study summary
Peripheral neuropathy is a frequent condition, commonly associated with pain. Repetitive Transcranial Magnetic Stimulation (rTMS) is a noninvasive method of modulation of brain plasticity and is regarded as one of alternative methods to alleviate pain associated with various kind of neuropathies. rTMS is usually performed once a day and the whole therapy of neuropathic pain lasts one week. In a number of recent clinical trials including patients with depression and some other disorders, rTMS was delivered several times a day, which reduced the time of the whole therapy. This approach was termed an accelerated rTMS. The purpose of this study is to investigate feasibility of accelerated rTMS in treatment of neuropathic pain.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Diagnosis of peripheral neuropathy
* Neuropathic pain of constant severity since not less than a month and requiring use of analgesics more than once a week
* Score of 30 millimeter or more on the 100 millimeter visual analog scale of pain intensity at inclusion
Exclusion Criteria:
* Severe depression
* Personality disorders and other psychiatric conditions, which could disturb the participation in the study
* Cognitive deficits, which could disturb the participation in the study
* Epilepsy
* Presence of magnetic material in the reach of magnetic field
* Pregnancy
* Likelihood to get pregnant
* Intracranial electrodes
Primary outcome measure(s)
Visual Analogue Scale of Pain Severity after rTMS — Through study completion, an average of 1 year. An analog scale of the length of 100 millimeter. Total score of 100, with higher scores representing more severe pain. Change from baseline score in the Visual Analogue Scale to the measurement taken after finishing rTMS.
Visual Analogue Scale of Pain Severity First Follow-up — Before rTMS, up to one day after finishing rTMS. An analog scale of the length of 100 millimeter. Total score of 100, with higher scores representing more severe pain. Change from baseline score in the Visual Analogue Scale to the measurement taken after two weeks after finishing rTMS.
Visual Analogue Scale of Pain Severity Second Follow-up — Before rTMS, four weeks after finishing rTMS. An analog scale of the length of 100 millimeter. Total score of 100, with higher scores representing more severe pain. Change from baseline score in the Visual Analogue Scale to the measurement taken after four weeks after finishing rTMS.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.
