Randomized Trial Comparing Fecal Testing (FIT) to Colonoscopy for Post-polypectomy Surveillance

NCT06983639 · tracked via the Priya Life Science Norway tracker

Sponsor

Sorlandet Hospital HF

Phase

Not applicable

Started

2026-01-09

Last updated

2026-01-15

Condition(s) studied

Colorectal Neoplasms

Investigational drug(s) / intervention(s)

Fecal occult blood testingColonoscopy

Fecal occult blood testing: Fecal testing for blood as surveillance efter polyp removal

Colonoscopy: Colonoscopy after polyp removal according to guidelines

Study summary

From observational studies, it is know that the risk of developing colorectal cancer after polyp removal is lower if the patients adheres to surveillance recommendations. However, colonoscopy is burdensome for patients and colonoscopy availability is limited in many parts of the world. In addition, more than half of surveillance colonoscopies are without any findings. The trial investigates whether surveillance using fecal testing for blod is as good as colonoscopy after removal of colorectal polyps.

Eligibility

Sex

ALL

Min age

40 Years

Max age

75 Years

Healthy volunteers

Inclusion Criteria: * High-quality baseline colonoscopy with adequat cleansing and cecal intubation * Remocval of at least one advanced adenoma * Clean colon (all polyps removed) * Signed informed consent Exclusion Criteria: * Colorectal cancer * History of surgical colon resection for any reason * Genetic cancer syndrome (adenomatous or serrated polyposis syndrome; Lynch or Lynch-like syndrome) * ≥ 10 adenomas at baseline colonoscopy (cumulative) * History of advanced serrated lesion, defined as SSL≥ 10mm or with dysplasia * Inflammatory bowel disease * On-going palliative care for any reason

Primary outcome measure(s)

Colorectal cancer incidence — 12 years from randomization

Trial sites (1)

Facility	City	Region	Status
Sørlandet sykehus HF	Arendal	Agder	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06983639 on ClinicalTrials.gov ↗ ← All trials in Norway