Early Discovery of Ischemia After Replantation Surgery of the Extremities

Condition(s) studied

Investigational drug(s) / intervention(s)

IscAlert: Insertion of a CO2- and temperature sensor in the distal part of the replanted extremity

Study summary

Investigators will test if changes in CO2 is detected postoperatively in ischemic tissue in a replanted extremity of a traumatically amputated upper or lower extremity. IscAlert is measuring continuously CO2 in muscular and subcutaneous tissue. IscAlert is inserted distal to the operative field into normal muscle and/or subcutaneous tissue in the replanted extremity. Local tissue CO2 and temperature will be monitored continuously postoperatively for the next 10 days. If a reduced or totally obstructed blood flow appear (thrombosis), an increase in tissue CO2 and a lower local temperature will emerge rapidly as a sign of ischemia. This will be detected by the sensor which will alarm the investigators. This will lead to assessment of the replanted extremity and if restricted blood flow is diagnosed, a reoperation will be performed. After reoperation new sensors will be implanted for another ten days if applicable. Sixty patients will be enrolled to undergo the procedures. The IscAlert will be removed from the patient before the patient is discharged from the hospital or a maximum of 10 days (the event that occurs first). 500 devices is planned to be used in this clinical study.

Eligibility

Primary outcome measure(s)

• Tissue CO2-level — 10 days
  Tissue CO2-level (kPa) during insertion period

Trial sites (1)

More Oslo University Hospital trials in Norway

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