Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest

Condition(s) studied

Investigational drug(s) / intervention(s)

Double sequential defibirllation: A second defibrillator will be applyed with electrodes placed in the A-P position and defibrillation will be performed with two defibrllators in a sequential manner

Standard defibrillation: Standard defibrillation uning one defibrillator

Study summary

Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation. The survival decreases with number of defibrillations required to terminate VF/VT. In 2022, one prospective cluster randomized trial showed increased survival among (OHCA) patients in refractory VF using Double Sequential Defibrillation (DSD). If DSD can increase survival among all patients in VF that dont respond to one defibrillation, i.e. before it has become refractory is not known.

The aim of this trial is to assess survival with a double defibrillation strategy initiated as soon as possible among patients with Out of Hospital Cardiac Arrest with initial shockable rhythm and at least one failed standard defibrillation, compared with continued resuscitation using standard defibrillation.

Eligibility

Primary outcome measure(s)

• 30 day survival — 30 days
  Survival at 30 days

Trial sites (14)

Other trials for the same condition